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Cadmium stimulates the expression of vascular cell adhesion molecule-1 (VCAM-1) via p38 mitogen-activated protein kinase (MAPK) and JNK activation in cerebrovascular endothelial cells.

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dc.contributor.authorPark, SL-
dc.contributor.authorKim, YM-
dc.contributor.authorAhn, JH-
dc.contributor.authorLee, SH-
dc.contributor.authorBaik, EJ-
dc.contributor.authorMoon, CH-
dc.contributor.authorJung, YS-
dc.date.accessioned2010-11-10T05:21:01Z-
dc.date.available2010-11-10T05:21:01Z-
dc.date.issued2009-
dc.identifier.issn1347-8613-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/182-
dc.description.abstractIn this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations of p38, JNK, and ERK. The Cd-induced VCAM-1 expression was significantly suppressed by either a specific p38 mitogen-activated protein kinase (MAPK) inhibitor (SB202190) or a JNK inhibitor (SP600125), but not by an ERK inhibitor (U0126). These results suggest that Cd induces the expression of VCAM-1, at least in part, via p38 and JNK pathways in bEnd.3 cells.-
dc.formattext/plain-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBrain/cytology-
dc.subject.MESHCadmium/pharmacology-
dc.subject.MESHEndothelium, Vascular/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHJNK Mitogen-Activated Protein Kinases/metabolism-
dc.subject.MESHMice-
dc.subject.MESHVascular Cell Adhesion Molecule-1/metabolism-
dc.subject.MESHp38 Mitogen-Activated Protein Kinases/metabolism-
dc.titleCadmium stimulates the expression of vascular cell adhesion molecule-1 (VCAM-1) via p38 mitogen-activated protein kinase (MAPK) and JNK activation in cerebrovascular endothelial cells.-
dc.typeArticle-
dc.identifier.pmid19609071-
dc.identifier.urlhttp://joi.jlc.jst.go.jp/JST.JSTAGE/jphs/09001SC?from=PubMed-
dc.contributor.affiliatedAuthor김, 유미-
dc.contributor.affiliatedAuthor이, 수환-
dc.contributor.affiliatedAuthor백, 은주-
dc.contributor.affiliatedAuthor문, 창현-
dc.contributor.affiliatedAuthor정, 이숙-
dc.type.localJournal Papers-
dc.citation.titleJournal of pharmacological sciences-
dc.citation.volume110-
dc.citation.number3-
dc.citation.date2009-
dc.citation.startPage405-
dc.citation.endPage409-
dc.identifier.bibliographicCitationJournal of pharmacological sciences, 110(3). : 405-409, 2009-
dc.identifier.eissn1347-8648-
dc.relation.journalidJ013478613-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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