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Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go.

Authors
Ghil, S; Choi, JM; Kim, SS; Lee, YD; Liao, Y; Birnbaumer, L; Suh-Kim, H
Citation
Proceedings of the National Academy of Sciences of the United States of America, 103(50):19158-19163, 2006
Journal Title
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-84241091-6490
Abstract
G(o), a member of the G(o/i) family, is the most abundant heterotrimeric G protein in brain. Most functions of G(o) are mediated by the G(betagamma) dimer; effector(s) for its alpha-subunit have not been clearly defined. Here we report that G(oalpha) interacts directly with cAMP-dependent protein kinase (PKA) through its GTPase domain. This interaction did not inhibit the kinase function of PKA but interfered with nuclear translocation of PKA while sparing its cytosolic function. This regulatory mechanism by which G(o) bifurcates PKA signaling may provide insights into how G(o) regulates complex processes such as neuritogenesis, synaptic plasticity, and cell transformation.
MeSH terms
AnimalsCell LineCell Nucleus/metabolismCercopithecus aethiopsCyclic AMP-Dependent Protein Kinases/metabolism*Cytosol/metabolismGTP-Binding Protein alpha Subunits, Gi-Go/geneticsGTP-Binding Protein alpha Subunits, Gi-Go/metabolism*HumansProtein BindingSignal Transduction*
DOI
10.1073/pnas.0609392103
PMID
17148597
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
AJOU Authors
김, 성수이, 영돈서, 해영
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