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Metabolic features and regulation in cell senescence

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dc.contributor.authorKwon, SM-
dc.contributor.authorHong, SM-
dc.contributor.authorLee, YK-
dc.contributor.authorMin, S-
dc.contributor.authorYoon, G-
dc.date.accessioned2020-10-21T07:20:14Z-
dc.date.available2020-10-21T07:20:14Z-
dc.date.issued2019-
dc.identifier.issn1976-6696-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18718-
dc.description.abstractOrganismal aging is accompanied by a host of progressive metabolic alterations and an accumulation of senescent cells, along with functional decline and the appearance of multiple diseases. This implies that the metabolic features of cell senescence may contribute to the organism's metabolic changes and be closely linked to age-associated diseases, especially metabolic syndromes. However, there is no clear understanding of senescent metabolic characteristics. Here, we review key metabolic features and regulators of cellular senescence, focusing on mitochondrial dysfunction and anabolic deregulation, and their link to other senescence phenotypes and aging. We further discuss the mechanistic involvement of the metabolic regulators mTOR, AMPK, and GSK3, proposing them as key metabolic switches for modulating senescence.-
dc.language.isoen-
dc.subject.MESHAdenylate Kinase-
dc.subject.MESHAging-
dc.subject.MESHAnimals-
dc.subject.MESHCellular Senescence-
dc.subject.MESHGlycogen Synthase Kinase 3-
dc.subject.MESHHumans-
dc.subject.MESHMitochondria-
dc.subject.MESHPhenotype-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTOR Serine-Threonine Kinases-
dc.titleMetabolic features and regulation in cell senescence-
dc.typeArticle-
dc.identifier.pmid30526768-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386228/-
dc.subject.keywordGlycogenesis-
dc.subject.keywordLipogenesis-
dc.subject.keywordMetabolic regulators-
dc.subject.keywordMitochondrial dysfunction-
dc.subject.keywordProtein synthesis-
dc.contributor.affiliatedAuthor권, 소미-
dc.contributor.affiliatedAuthor홍, 선미-
dc.contributor.affiliatedAuthor이, 영경-
dc.contributor.affiliatedAuthor윤, 계순-
dc.type.localJournal Papers-
dc.identifier.doi10.5483/BMBRep.2019.52.1.291-
dc.citation.titleBMB reports-
dc.citation.volume52-
dc.citation.number1-
dc.citation.date2019-
dc.citation.startPage5-
dc.citation.endPage12-
dc.identifier.bibliographicCitationBMB reports, 52(1). : 5-12, 2019-
dc.identifier.eissn1976-670X-
dc.relation.journalidJ019766696-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > Research Organization > Inflamm-aging Translational Research Center
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