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Low-dose midazolam and propofol use for conscious sedation during diagnostic endoscopy

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dc.contributor.authorKim, JH-
dc.contributor.authorKim, DH-
dc.contributor.authorKim, JH-
dc.date.accessioned2020-10-21T07:20:17Z-
dc.date.available2020-10-21T07:20:17Z-
dc.date.issued2019-
dc.identifier.issn1607-551X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18727-
dc.description.abstractTo find the right sedation technique for different types of treatment methods and the right amount of sedatives so the chances of side effects happening can be reduced. This was a retrospective cohort analysis conducted on prospectively collected data. Patients who underwent esophagogastroduodenoscopy only (E group) were sub-divided into two subgroups: (a) Those who received 0.5 mg/kg of propofol (E-a), (b) Those who received 0.025 mg/kg of midazolam and 0.5 mg/kg of propofol (E-b). Patients who underwent esophagogastroduodenoscopy with colonoscopy (EC group) were also sub-divided into three subgroups: (a) Those who received 0.5 mg/kg of propofol (EC-a), (b) Those who received 0.025 mg/kg of midazolam and 0.5 mg/kg of propofol (EC-b), (c) Those who received 25 mg (12.5 mg if body weight < 50 kg or age > 70) of meperidine and 0.025 mg/kg of midazolam along with 0.5 mg/kg of propofol (EC-c). When the level of target was not reached, 10-20 mg of propofol was additionally injected. Sedation efficacy and safety were then compared among groups. E-b and EC-b decreased the overall amount of propofol and reduced side effect of temporary hypoxemia compared to E-a and EC-a. EC-b shortened patient recovery time compared to EC-c and reduced paradoxical reaction. In terms of the patient satisfaction and patient cooperation by endoscopists, there were no significant differences between EC-b and EC-c. Concomitant use of low dosages of both propofol and midazolam is found to be useful and safe when endoscopy needs to be performed.-
dc.language.isoen-
dc.subject.MESHColonoscopy-
dc.subject.MESHConscious Sedation-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHEndoscopy, Digestive System / adverse effects-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMidazolam / pharmacology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPropofol / pharmacology-
dc.titleLow-dose midazolam and propofol use for conscious sedation during diagnostic endoscopy-
dc.typeArticle-
dc.identifier.pmid30887720-
dc.subject.keywordconscious sedation-
dc.subject.keywordendoscopy-
dc.subject.keywordmidazolam-
dc.subject.keywordpropofol-
dc.contributor.affiliatedAuthor김, 주형-
dc.contributor.affiliatedAuthor김, 진홍-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/kjm2.12028-
dc.citation.titleThe Kaohsiung journal of medical sciences-
dc.citation.volume35-
dc.citation.number3-
dc.citation.date2019-
dc.citation.startPage160-
dc.citation.endPage167-
dc.identifier.bibliographicCitationThe Kaohsiung journal of medical sciences, 35(3). : 160-167, 2019-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.relation.journalidJ01607551X-
Appears in Collections:
Journal Papers > Research Organization > Ajou Medical Research Collaborating Center
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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