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Real-life effectiveness of inhaler device switch from dry powder inhalers to pressurized metred-dose inhalers in patients with asthma treated with ICS/LABA

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dc.contributor.authorPark, HS-
dc.contributor.authorYoon, D-
dc.contributor.authorLee, HY-
dc.contributor.authorBan, GY-
dc.contributor.authorWan Yau Ming, S-
dc.contributor.authorJie, JLZ-
dc.contributor.authorCarter, V-
dc.contributor.authorHardjojo, A-
dc.contributor.authorVan Boven, JFM-
dc.contributor.authorPrice, DB-
dc.date.accessioned2020-10-21T07:20:23Z-
dc.date.available2020-10-21T07:20:23Z-
dc.date.issued2019-
dc.identifier.issn1323-7799-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18743-
dc.description.abstractBACKGROUND AND OBJECTIVE: Mixed inhaler device use for asthma is associated with worse inhaler technique and outcomes. Given that relievers are commonly prescribed as pressurized metred-dose inhalers (pMDI), changing preventers from dry powder inhalers (DPI) to pMDI may improve asthma outcomes. This study aimed to assess the persistence and effectiveness of switching from DPI to pMDI for inhaled corticosteroid and long-acting beta2 -agonist combination therapy (ICS/LABA).
METHODS: This was a historical cohort study using Ajou University Hospital (Korea) patient records. Persistence of switch was defined as receiving >/=1 pMDI and no DPI after the switch. Effectiveness of switch was assessed as the proportion without severe asthma exacerbation and the proportion achieving risk domain asthma control (RDAC: no asthma-related hospitalization, antibiotics without upper respiratory diagnosis or acute course of oral corticosteroids) and overall asthma control (OAC: RDAC and RESULTS: Within 85 patients who switched from DPI to pMDI and persisted for a year, higher proportion were free from asthma exacerbation after the switch (mean difference in proportion = 0.129, 95% CI: 0.038-0.220). Switching to pMDI was also associated with better RDAC (75.3% vs 57.7%, P = 0.001) and OAC (57.7% vs 45.9%, P = 0.021). From the entire 117 patients who switched to fixed-dose combination (FDC)/ICS LABA pMDI, 76.1% (95% CI: 69.0-100.0%) patients persisted in the following 6 months.
CONCLUSION: Switching to and persisting with pMDI was associated with decreased asthma exacerbations and improved asthma control. The majority of patients persisted with the switch to pMDI for ICS/LABA treatment.
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dc.language.isoen-
dc.subject.MESHAdministration, Inhalation-
dc.subject.MESHAdolescent-
dc.subject.MESHAdrenal Cortex Hormones / administration & dosage-
dc.subject.MESHAdrenergic beta-2 Receptor Agonists / administration & dosage-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlbuterol / administration & dosage-
dc.subject.MESHAsthma / drug therapy-
dc.subject.MESHChild-
dc.subject.MESHDisease Progression-
dc.subject.MESHDry Powder Inhalers-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMetered Dose Inhalers-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTerbutaline / administration & dosage-
dc.subject.MESHYoung Adult-
dc.titleReal-life effectiveness of inhaler device switch from dry powder inhalers to pressurized metred-dose inhalers in patients with asthma treated with ICS/LABA-
dc.typeArticle-
dc.identifier.pmid31038269-
dc.subject.keywordasthma-
dc.subject.keyworddry powder inhaler-
dc.subject.keywordmedication persistence-
dc.subject.keywordmetred-dose inhaler-
dc.subject.keywordtreatment efficacy-
dc.contributor.affiliatedAuthor박, 해심-
dc.contributor.affiliatedAuthor윤, 덕용-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/resp.13559-
dc.citation.titleRespirology (Carlton, Vic.)-
dc.citation.volume24-
dc.citation.number10-
dc.citation.date2019-
dc.citation.startPage972-
dc.citation.endPage979-
dc.identifier.bibliographicCitationRespirology (Carlton, Vic.), 24(10). : 972-979, 2019-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1440-1843-
dc.relation.journalidJ013237799-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
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