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Surfactant protein D alleviates eosinophil-mediated airway inflammation and remodeling in patients with aspirin-exacerbated respiratory disease

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dc.contributor.authorChoi, Y-
dc.contributor.authorLee, DH-
dc.contributor.authorTrinh, HKT-
dc.contributor.authorBan, GY-
dc.contributor.authorPark, HK-
dc.contributor.authorShin, YS-
dc.contributor.authorKim, SH-
dc.contributor.authorPark, HS-
dc.date.accessioned2020-10-21T07:20:24Z-
dc.date.available2020-10-21T07:20:24Z-
dc.date.issued2019-
dc.identifier.issn0105-4538-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18745-
dc.description.abstractBACKGROUND: Surfactant protein D (SPD) is a member of the collectin family that lines the airway epithelial cells with host defense. However, the role of SPD in the pathogenesis of aspirin-exacerbated respiratory disease (AERD) is still unclear.
METHODS: The serum SPD level was measured in patients with AERD (n = 336), those with aspirin-tolerant asthma (ATA, n = 442), and healthy controls (HC, n = 104). Polymorphisms of SFTPD in the study subjects were analyzed. The effect of LTE4 on SPD production through eosinophil infiltration was investigated in BALB/c mice. The protective function of SPD against eosinophils inducing inflammation and remodeling was assessed in vitro/vivo. The potential efficacy of nintedanib against airway remodeling through the production of SPD was evaluated.
RESULTS: The serum SPD level was significantly lower (P < .001) in AERD compared with ATA patients, and negatively correlated with fall in FEV1 (%) after lysine-aspirin bronchoprovocation test and/or the urinary LTE4 level. In addition, polymorphism of SFTPD at rs721917 was significantly different in the study subjects (odds ratio, 1.310: 95% confidence intervals, 2.124-3.446: P = .002). LTE4-exposed mice showed an increased eosinophil count with a decreased SPD level in bronchoalveolar lavage fluid. Eosinophils increased alpha-smooth muscle actin expression in airway epithelial cells, which was attenuated by SPD treatment. Furthermore, nintedanib protected the airway epithelial cells against eosinophils by enhancing the production of SPD.
CONCLUSION: The decreased level of SPD in AERD was associated with airway inflammation/remodeling under the eosinophilic condition, suggesting that modulation of SPD may provide a potential benefit in AERD.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAirway Remodeling-
dc.subject.MESHAnimals-
dc.subject.MESHAsthma, Aspirin-Induced-
dc.subject.MESHEosinophils-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIndoles-
dc.subject.MESHInflammation-
dc.subject.MESHLeukotriene E4-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPulmonary Surfactant-Associated Protein D-
dc.subject.MESHRespiratory System-
dc.titleSurfactant protein D alleviates eosinophil-mediated airway inflammation and remodeling in patients with aspirin-exacerbated respiratory disease-
dc.typeArticle-
dc.identifier.pmid29663427-
dc.subject.keywordaspirin-exacerbated respiratory disease-
dc.subject.keywordeosinophils-
dc.subject.keywordinflammation-
dc.subject.keywordremodeling-
dc.subject.keywordsurfactant protein D-
dc.contributor.affiliatedAuthor신, 유섭-
dc.contributor.affiliatedAuthor김, 승현-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/all.13458-
dc.citation.titleAllergy-
dc.citation.volume74-
dc.citation.number1-
dc.citation.date2019-
dc.citation.startPage78-
dc.citation.endPage88-
dc.identifier.bibliographicCitationAllergy, 74(1). : 78-88, 2019-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1398-9995-
dc.relation.journalidJ001054538-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Hospital > Clinical Trial Center
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