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Intratumoral heterogeneity as measured using the tumor-stroma ratio and PET texture analyses in females with lung adenocarcinomas differs from that of males with lung adenocarcinomas or squamous cell carcinomas

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dc.contributor.authorKoh, YW-
dc.contributor.authorLee, D-
dc.contributor.authorLee, SJ-
dc.date.accessioned2020-10-21T07:20:26Z-
dc.date.available2020-10-21T07:20:26Z-
dc.date.issued2019-
dc.identifier.issn0025-7974-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18752-
dc.description.abstractWe compared intratumoral stromal proportions and positron emission tomography (PET) textural features between females and males with lung adenocarcinoma (ADC) or squamous cell carcinoma (SCC).We retrospectively evaluated 167 consecutive patients (male 122, female 45) who underwent pretreatment fluorodeoxyglucose PET/CT and surgical resection. The tumor-stroma ratios (TSRs) of primary tumors were estimated on hematoxylin-and-eosin-stained histological sections, and higher-order textural features were extracted on PET. We compared the histological and PET features between the sexes.More females than males had ADC. Age and pathological tumor size did not significantly differ between females and males. Females with ADC had more stroma-rich tumors than males with ADC (P = .016) or SCC (P = .047). In addition, some PET textural features significantly differed between females with ADC and males with ADC and SCC: short run emphasis, long run emphasis, coarseness, strength, short-zone emphasis, zone percentage and high-intensity large-zone percentage were the commonly differed textural features. However, the TSRs and PET textural features did not significantly differ between males with ADC or SCC.Intratumoral heterogeneity in females with lung ADC differs from that in males with lung ADC or SCC.-
dc.language.isoen-
dc.subject.MESHAdenocarcinoma of Lung-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Squamous Cell-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasms-
dc.subject.MESHPositron Emission Tomography Computed Tomography-
dc.subject.MESHRadiopharmaceuticals-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSex Factors-
dc.titleIntratumoral heterogeneity as measured using the tumor-stroma ratio and PET texture analyses in females with lung adenocarcinomas differs from that of males with lung adenocarcinomas or squamous cell carcinomas-
dc.typeArticle-
dc.identifier.pmid30882693-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426613/-
dc.subject.keywordadenocarcinoma of lung-
dc.subject.keywordfemale-
dc.subject.keywordpositron emission tomography-
dc.subject.keywordtexture analysis-
dc.subject.keywordtumor-stroma ratio-
dc.contributor.affiliatedAuthor고, 영화-
dc.contributor.affiliatedAuthor이, 다근-
dc.contributor.affiliatedAuthor이, 수진-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/MD.0000000000014876-
dc.citation.titleMedicine-
dc.citation.volume98-
dc.citation.number11-
dc.citation.date2019-
dc.citation.startPagee14876-
dc.citation.endPagee14876-
dc.identifier.bibliographicCitationMedicine, 98(11). : e14876-e14876, 2019-
dc.identifier.eissn1536-5964-
dc.relation.journalidJ000257974-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
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