74 261

Cited 0 times in

Cellular senescence in cancer

DC Field Value Language
dc.contributor.authorKim, YH-
dc.contributor.authorPark, TJ-
dc.date.accessioned2020-10-21T07:20:47Z-
dc.date.available2020-10-21T07:20:47Z-
dc.date.issued2019-
dc.identifier.issn1976-6696-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18802-
dc.description.abstractCellular senescence, a process of cell proliferation arrest in response to various stressors, has been considered to be important factor in age-related disease. Identification of senescent cells in tissues is limited and the role of senescent cells is poorly understood. Recently however, several studies showed the characterization of senescent cells in various pathologic conditions and the role of senescent cells in disease progression is becoming important. Senescent cells are growth-arrested cells, however, the senescence associated secretory phenotype (SASP) of senescent cells could modify the tissues' microenvironment. Here, we discuss the progress and understanding of the role of senescent cells in tissues of pathologic conditions and discuss the development of new therapeutic paradigms, such as senescent cells-targeted therapy.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHCarcinogenesis / metabolism-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCell Transformation, Neoplastic-
dc.subject.MESHCellular Senescence / physiology-
dc.subject.MESHChemokine CXCL12 / physiology-
dc.subject.MESHHumans-
dc.subject.MESHNeoplasms / physiopathology-
dc.subject.MESHPhenotype-
dc.titleCellular senescence in cancer-
dc.typeArticle-
dc.identifier.pmid30526772-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386235/-
dc.subject.keywordCancer-
dc.subject.keywordCXCL12-
dc.subject.keywordSASP-
dc.subject.keywordSA--Gal-
dc.subject.keywordSenescence-
dc.contributor.affiliatedAuthor박, 태준-
dc.type.localJournal Papers-
dc.identifier.doi10.5483/BMBRep.2019.52.1.295-
dc.citation.titleBMB reports-
dc.citation.volume52-
dc.citation.number1-
dc.citation.date2019-
dc.citation.startPage42-
dc.citation.endPage46-
dc.identifier.bibliographicCitationBMB reports, 52(1). : 42-46, 2019-
dc.identifier.eissn1976-670X-
dc.relation.journalidJ019766696-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Files in This Item:
30526772.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse