Cited 0 times in Scipus Cited Count

Development of the clinical assessment scale in autoimmune encephalitis

DC Field Value Language
dc.contributor.authorLim, JA-
dc.contributor.authorLee, ST-
dc.contributor.authorMoon, J-
dc.contributor.authorJun, JS-
dc.contributor.authorKim, TJ-
dc.contributor.authorShin, YW-
dc.contributor.authorAbdullah, S-
dc.contributor.authorByun, JI-
dc.contributor.authorSunwoo, JS-
dc.contributor.authorKim, KT-
dc.contributor.authorYang, TW-
dc.contributor.authorLee, WJ-
dc.contributor.authorMoon, HJ-
dc.contributor.authorKim, DW-
dc.contributor.authorLim, BC-
dc.contributor.authorCho, YW-
dc.contributor.authorYang, TH-
dc.contributor.authorKim, HJ-
dc.contributor.authorKim, YS-
dc.contributor.authorKoo, YS-
dc.contributor.authorPark, B-
dc.contributor.authorJung, KH-
dc.contributor.authorKim, M-
dc.contributor.authorPark, KI-
dc.contributor.authorJung, KY-
dc.contributor.authorChu, K-
dc.contributor.authorLee, SK-
dc.date.accessioned2020-10-21T07:20:58Z-
dc.date.available2020-10-21T07:20:58Z-
dc.date.issued2019-
dc.identifier.issn0364-5134-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18834-
dc.description.abstractOBJECTIVE: There is no scale for rating the severity of autoimmune encephalitis (AE). In this study, we aimed to develop a novel scale for rating severity in patients with diverse AE syndromes and to verify the reliability and validity of the developed scale.
METHODS: The key items were generated by a panel of experts and selected according to content validity ratios. The developed scale was initially applied to 50 patients with AE (development cohort) to evaluate its acceptability, reproducibility, internal consistency, and construct validity. Then, the scale was applied to another independent cohort (validation cohort, n = 38).
RESULTS: A new scale consisting of 9 items (seizure, memory dysfunction, psychiatric symptoms, consciousness, language problems, dyskinesia/dystonia, gait instability and ataxia, brainstem dysfunction, and weakness) was developed. Each item was assigned a value of up to 3 points. The total score could therefore range from 0 to 27. We named the scale the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). The new scale showed excellent interobserver (intraclass correlation coefficient [ICC] = 0.97) and intraobserver (ICC = 0.96) reliability for total scores, was highly correlated with modified Rankin scale (r = 0.86, p < 0.001), and had acceptable internal consistency (Cronbach alpha = 0.88). Additionally, in the validation cohort, the scale showed high interobserver reliability (ICC = 0.99) and internal consistency (Cronbach alpha = 0.92).
INTERPRETATION: CASE is a novel clinical scale for AE with a high level of clinimetric properties. It would be suitable for application in clinical practice and might help overcome the limitations of current outcome scales for AE.
-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAggression-
dc.subject.MESHAnti-N-Methyl-D-Aspartate Receptor Encephalitis-
dc.subject.MESHAtaxia-
dc.subject.MESHAutoimmune Diseases-
dc.subject.MESHAutoimmune Diseases of the Nervous System-
dc.subject.MESHDelusions-
dc.subject.MESHDyskinesias-
dc.subject.MESHDystonia-
dc.subject.MESHEncephalitis-
dc.subject.MESHEncephalomyelitis, Acute Disseminated-
dc.subject.MESHFemale-
dc.subject.MESHGait Disorders, Neurologic-
dc.subject.MESHHallucinations-
dc.subject.MESHHumans-
dc.subject.MESHLanguage Disorders-
dc.subject.MESHLimbic Encephalitis-
dc.subject.MESHMale-
dc.subject.MESHMemory Disorders-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMuscle Weakness-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSeizures-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHYoung Adult-
dc.titleDevelopment of the clinical assessment scale in autoimmune encephalitis-
dc.typeArticle-
dc.identifier.pmid30675918-
dc.contributor.affiliatedAuthor김, 태준-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/ana.25421-
dc.citation.titleAnnals of neurology-
dc.citation.volume85-
dc.citation.number3-
dc.citation.date2019-
dc.citation.startPage352-
dc.citation.endPage358-
dc.identifier.bibliographicCitationAnnals of neurology, 85(3). : 352-358, 2019-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1531-8249-
dc.relation.journalidJ003645134-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse