Cited 0 times in Scipus Cited Count

An alternatively spliced form of Met receptor is tumorigenic.

DC Field Value Language
dc.contributor.authorLee, JH-
dc.contributor.authorGao, CF-
dc.contributor.authorLee, CC-
dc.contributor.authorKim, MD-
dc.contributor.authorVande Woude, GF-
dc.date.accessioned2011-03-23T06:10:23Z-
dc.date.available2011-03-23T06:10:23Z-
dc.date.issued2006-
dc.identifier.issn1226-3613-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1883-
dc.description.abstractThe Met tyrosine kinase receptor is a widely expressed molecule, which mediates pleiotropic cellular responses following activation by its ligand, hepatocyte growth factor/scatter factor (HGF/SF). Previously, one of the authors identified an alternatively spliced form of Met (Met-SM) that lacked a single exon of a 47-amino-acid segment in the juxtamembrane domain. Here we report that Met-SM is a potent transforming gene in NIH3T3 mouse fibroblast cells. Met-SM-transfected NIH3T3 cells show stronger foci-forming activity than wild type- Met-transfected ones. In addition, Met-SM-transfected NIH3T3 cells form colonies in soft agar and are tumorigenic in athymic nu/nu mice. Furthermore, HGF/SF significantly increases the focus-forming activity of Met-SM comparing to wild type Met. The amount of protein and of tyrosine kinase activity of Met-SM accumulates to a high level following HGF/SF treatment. The accumulation of Met-SM correlated well with its delayed ubiquitination and increased stability. These results are consistent with the important role of the juxtamembrane domain in protein stability of Met receptor and suggest that the alternatively-spliced form may contribute to the development and progression of human cancer.-
dc.language.isoen-
dc.subject.MESHAlternative Splicing-
dc.subject.MESHAnimals-
dc.subject.MESHCarcinogenicity Tests-
dc.subject.MESHCarcinogens-
dc.subject.MESHDown-Regulation-
dc.subject.MESHFemale-
dc.subject.MESHHepatocyte Growth Factor-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHMutant Proteins-
dc.subject.MESHNIH 3T3 Cells-
dc.subject.MESHProtein Isoforms-
dc.subject.MESHProto-Oncogene Proteins c-met-
dc.titleAn alternatively spliced form of Met receptor is tumorigenic.-
dc.typeArticle-
dc.identifier.pmid17079873-
dc.identifier.urlhttp://www.e-emm.org/search_read.htm?page=565&year=2006&vol=38-
dc.contributor.affiliatedAuthor이, 재호-
dc.type.localJournal Papers-
dc.identifier.doi10.1038/emm.2006.66-
dc.citation.titleExperimental & molecular medicine-
dc.citation.volume38-
dc.citation.number5-
dc.citation.date2006-
dc.citation.startPage565-
dc.citation.endPage573-
dc.identifier.bibliographicCitationExperimental & molecular medicine, 38(5). : 565-573, 2006-
dc.identifier.eissn2092-6413-
dc.relation.journalidJ012263613-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Files in This Item:
17079873.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse