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Prevalence and Characteristics of Restless Legs Syndrome in Korean Adults: A Study in Two Independent Samples of the General Population

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dc.contributor.authorKim, TJ-
dc.contributor.authorYoon, JE-
dc.contributor.authorPark, JA-
dc.contributor.authorLee, SK-
dc.contributor.authorChu, MK-
dc.contributor.authorYang, KI-
dc.contributor.authorKim, WJ-
dc.contributor.authorPark, SH-
dc.contributor.authorThomas, RJ-
dc.contributor.authorShin, C-
dc.contributor.authorYun, CH-
dc.date.accessioned2020-10-21T07:21:08Z-
dc.date.available2020-10-21T07:21:08Z-
dc.date.issued2019-
dc.identifier.issn0251-5350-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18863-
dc.description.abstractBACKGROUND: Restless legs syndrome (RLS) is a common sleep disorder, although it has a low prevalence in Asian populations. However, the reported RLS prevalence in -Korean adults is mostly 4.5-12.1%, which is higher than that reported in other Asian populations. This study aimed to diagnose RLS and exclude mimicking conditions in 2 independent samples of Korean adults, and to compare its prevalence to that from previous studies performed in Asian countries.
METHODS: Study populations included a (1) nationwide stratified random sample (n = 2,824: age 19-79 years) and (2) community-based cohort (n = 2,685: age 47-79 years). We applied the Cambridge-Hopkins diagnostic questionnaire to diagnose RLS and differentiate it from RLS mimics. Sleep-related symptoms, mood, and medical conditions were compared between the RLS and non-RLS groups. Prior studies of the RLS prevalence in Asia were systematically reviewed and compared to our findings.
RESULTS: The adjusted RLS prevalence was 0.4 and 1.3% in populations 1 and 2, respectively. In both populations, subjects with RLS had more depression. The prevalence of RLS mimics was 5.1 and 2.6%, in populations 1 and 2, respectively. The RLS prevalence in Asia was higher when RLS was defined by the presence of essential clinical features and lower when a differential diagnosis was additionally implemented.
CONCLUSIONS: The RLS prevalence in Korean adults considering RLS mimics is comparable to that in adults from other Asian countries (< 2%). The reported RLS prevalence varies depending on the diagnostic method employed.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCohort Studies-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPopulation Surveillance-
dc.subject.MESHPrevalence-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRestless Legs Syndrome-
dc.subject.MESHYoung Adult-
dc.titlePrevalence and Characteristics of Restless Legs Syndrome in Korean Adults: A Study in Two Independent Samples of the General Population-
dc.typeArticle-
dc.identifier.pmid30763945-
dc.subject.keywordCambridge-Hopkins diagnostic questionnaire-
dc.subject.keywordEpidemiology-
dc.subject.keywordRestless legs syndrome-
dc.contributor.affiliatedAuthor김, 태준-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000496839-
dc.citation.titleNeuroepidemiology-
dc.citation.volume52-
dc.citation.number3-4-
dc.citation.date2019-
dc.citation.startPage193-
dc.citation.endPage204-
dc.identifier.bibliographicCitationNeuroepidemiology, 52(3-4). : 193-204, 2019-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1423-0208-
dc.relation.journalidJ002515350-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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