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Which Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease?

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dc.contributor.authorChoi, Y-
dc.contributor.authorLee, Y-
dc.contributor.authorPark, HS-
dc.date.accessioned2020-10-21T07:21:21Z-
dc.date.available2020-10-21T07:21:21Z-
dc.date.issued2019-
dc.identifier.issn2092-7355-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18905-
dc.description.abstractEosinophils have long been recognized as a central effector cell in the lungs of asthmatic patients. They contribute to airway inflammation and remodeling through releasing several molecules such as cytokines, granule proteins, lipid mediators and extracellular traps/vesicles. Repeated evidence reveals that intense eosinophil infiltration in upper and lower airway mucosae contributes to the pathogenesis of aspirin-exacerbated respiratory disease (AERD). Persistent eosinophilia is found to be associated with type 2 immune responses, cysteinyl leukotriene overproduction and eosinophil-epithelium interactions. This review highlights recent findings about key mechanisms of eosinophil activation in the airway inflammation of AERD. In addition, current biologics (targeting type 2 immune responses) were suggested to control eosinophilic inflammation for AERD patients.-
dc.language.isoen-
dc.titleWhich Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease?-
dc.typeArticle-
dc.identifier.pmid30912322-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439191/-
dc.subject.keywordEosinophils-
dc.subject.keywordepithelium-
dc.subject.keywordtherapy-
dc.contributor.affiliatedAuthor이, 영수-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.4168/aair.2019.11.3.320-
dc.citation.titleAllergy, asthma & immunology research-
dc.citation.volume11-
dc.citation.number3-
dc.citation.date2019-
dc.citation.startPage320-
dc.citation.endPage329-
dc.identifier.bibliographicCitationAllergy, asthma & immunology research, 11(3). : 320-329, 2019-
dc.identifier.eissn2092-7363-
dc.relation.journalidJ020927355-
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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