Cited 0 times in Scipus Cited Count

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are associated with disease activity in polymyalgia rheumatica

DC Field Value Language
dc.contributor.authorJung, JY-
dc.contributor.authorLee, E-
dc.contributor.authorSuh, CH-
dc.contributor.authorKim, HA-
dc.date.accessioned2020-11-17T05:25:09Z-
dc.date.available2020-11-17T05:25:09Z-
dc.date.issued2019-
dc.identifier.issn0887-8013-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/19013-
dc.description.abstractBACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are indicators of systemic inflammation and are useful as markers in systemic rheumatic diseases. In this study, we compared the NLR, PLR, and MLR among patients with polymyalgia rheumatica (PMR) and rheumatoid arthritis (RA), and explored possible associations with clinical features, disease activity, and prognosis in patients with PMR.
METHODS: The study enrolled 94 patients with PMR and 242 patients with RA who were initially diagnosed at the rheumatology clinic of a university-based tertiary hospital. Symptoms, physical examination, and medical histories were collected with the results of laboratory tests.
RESULTS: Neutrophil-to-lymphocyte ratio (4.5 +/- 3.3 vs 2.8 +/- 1.8), PLR (222.7 +/- 115.5 vs 159.7 +/- 78.1), and MLR (0.4 +/- 0.3 vs 0.3 +/- 0.2) were higher in patients with PMR compared with patients with RA (all P < .001). NLR, PLR, and MLR were correlated with specific laboratory values, including CRP and albumin, in patients with PMR. After disease activity resolved, NLR (2.95 +/- 2.32, P < .001), PLR (137.5 +/- 82.3, P < .001), and MLR (0.26 +/- 0.16, P < .001) decreased significantly. By comparing patients according to the disease course, swollen joint counts were higher in the chronic course group compared with the remission group (P = .03), while the NLR, PLR, and MLR were similar.
CONCLUSIONS: Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio levels were associated with disease activity and specific clinical features, although they could not predict prognosis in patients with PMR.
-
dc.language.isoen-
dc.subject.MESHArthritis, Rheumatoid-
dc.subject.MESHBiomarkers-
dc.subject.MESHBlood Platelets-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLymphocytes-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMonocytes-
dc.subject.MESHNeutrophils-
dc.subject.MESHPolymyalgia Rheumatica-
dc.titleNeutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are associated with disease activity in polymyalgia rheumatica-
dc.typeArticle-
dc.identifier.pmid31402523-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868401/-
dc.subject.keywordneutrophil-to-lymphocyte ratio-
dc.subject.keywordpolymyalgia rheumatica-
dc.subject.keywordprognosis-
dc.contributor.affiliatedAuthor정, 주양-
dc.contributor.affiliatedAuthor서, 창희-
dc.contributor.affiliatedAuthor김, 현아-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/jcla.23000-
dc.citation.titleJournal of clinical laboratory analysis-
dc.citation.volume33-
dc.citation.number9-
dc.citation.date2019-
dc.citation.startPagee23000-
dc.citation.endPagee23000-
dc.identifier.bibliographicCitationJournal of clinical laboratory analysis, 33(9). : e23000-e23000, 2019-
dc.identifier.eissn1098-2825-
dc.relation.journalidJ008878013-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Files in This Item:
31402523.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse