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Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Authors
Mun, DG | Bhin, J | Kim, S | Kim, H | Jung, JH | Jung, Y | Jang, YE | Park, JM | Kim, H | Jung, Y | Lee, H | Bae, J | Back, S | Kim, SJ | Kim, J | Park, H | Li, H | Hwang, KB | Park, YS | Yook, JH | Kim, BS | Kwon, SY | Ryu, SW | Park, DY | Jeon, TY | Kim, DH | Lee, JH | Han, SU  | Song, KS | Park, D | Park, JW | Rodriguez, H | Kim, J | Lee, H | Kim, KP | Yang, EG | Kim, HK | Paek, E | Lee, S | Lee, SW | Hwang, D
Citation
Cancer cell, 35(1). : 111-124.e1-e10, 2019
Journal Title
Cancer cell
ISSN
1535-61081878-3686
Abstract
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively: and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.
Keywords

MeSH

DOI
10.1016/j.ccell.2018.12.003
PMID
30645970
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Ajou Authors
한, 상욱
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