Cited 0 times in Scipus Cited Count

Maternal Perinatal Dietary Patterns Affect Food Allergy Development in Susceptible Infants

DC Field Value Language
dc.contributor.authorKim, YH-
dc.contributor.authorKim, KW-
dc.contributor.authorLee, SY-
dc.contributor.authorKoo, KO-
dc.contributor.authorKwon, SO-
dc.contributor.authorSeo, JH-
dc.contributor.authorSuh, DI-
dc.contributor.authorShin, YH-
dc.contributor.authorAhn, K-
dc.contributor.authorOh, SY-
dc.contributor.authorLee, S-
dc.contributor.authorSohn, MH-
dc.contributor.authorHong, SJ-
dc.date.accessioned2020-11-17T05:29:42Z-
dc.date.available2020-11-17T05:29:42Z-
dc.date.issued2019-
dc.identifier.issn2213-2198-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/19093-
dc.description.abstractBACKGROUND: The increasing incidence of food allergy (FA) can be attributed to interactions between genes and the environment, but these interactions are not yet fully clear.
OBJECTIVE: We aimed to evaluate the interaction between infant genetic variations and maternal dietary patterns to identify risk factors in the development of FA.
METHODS: We used the Cohort for Childhood Origin of Asthma and allergic diseases birth cohort of 1628 infants, born between 2007 and 2015. Maternal dietary intakes were assessed at 26 weeks of pregnancy using a food frequency questionnaire and grouped according to 5 dietary patterns. Infant cord blood samples were genotyped at 12 loci.
RESULTS: Among 1628 infants, 147 (9.0%) were diagnosed with FA based on history. A maternal confectionery diet characterized by a higher intake of baked and sugary products during pregnancy was associated with a higher prevalence of FA (adjusted odds ratio [OR] = 1.517, P = .02): this dietary pattern tended to be higher in trans fat (r = 0.498, P < .001). Development of FA was associated with longer periods of breastfeeding (adjusted OR = 1.792, P = .03), and this dietary pattern was more significantly related to the development of FA in infants with the homozygous TT genotype of CD14 (rs2569190) and more than 1 copy of GSTM1 and GSTT1.
CONCLUSIONS: A maternal confectionery diet during pregnancy that majorly consists of baked and sugary products, combined with a longer ensuing period of breastfeeding, may lead to the development of FA, suggesting a harmful effect of trans fats in the infant. Polymorphisms in CD14 and GST in the infant influence FA susceptibility.
-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHBreast Feeding-
dc.subject.MESHDiet-
dc.subject.MESHDietary Carbohydrates-
dc.subject.MESHFemale-
dc.subject.MESHFood Hypersensitivity-
dc.subject.MESHGene-Environment Interaction-
dc.subject.MESHGenetic Variation-
dc.subject.MESHGenotype-
dc.subject.MESHGlutathione Transferase-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHLipopolysaccharide Receptors-
dc.subject.MESHMaternal Nutritional Physiological Phenomena-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPregnancy-
dc.subject.MESHTrans Fatty Acids-
dc.titleMaternal Perinatal Dietary Patterns Affect Food Allergy Development in Susceptible Infants-
dc.typeArticle-
dc.identifier.pmid30930272-
dc.subject.keywordCD14-
dc.subject.keywordConfectionary-
dc.subject.keywordDietary pattern-
dc.subject.keywordFatty acids-
dc.subject.keywordFood allergy-
dc.subject.keywordGST-
dc.subject.keywordGenetics-
dc.subject.keywordInfant-
dc.subject.keywordPerinatal-
dc.subject.keywordPolymorphism-
dc.contributor.affiliatedAuthor이, 수영-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jaip.2019.03.026-
dc.citation.titleThe journal of allergy and clinical immunology. In practice-
dc.citation.volume7-
dc.citation.number7-
dc.citation.date2019-
dc.citation.startPage2337-
dc.citation.endPage2347.e1-e7-
dc.identifier.bibliographicCitationThe journal of allergy and clinical immunology. In practice, 7(7). : 2337-2347.e1-e7, 2019-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn2213-2201-
dc.relation.journalidJ022132198-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse