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Comparison of fractional myocardial mass, a vessel-specific myocardial mass-at-risk, with coronary angiographic scoring systems for predicting myocardial ischemia

Authors
Kim, HY | Doh, JH | Lim, HS  | Nam, CW | Shin, ES | Koo, BK | Lee, JM | Park, TK | Yang, JH | Song, YB | Hahn, JY | Choi, SH | Gwon, HC | Lee, SH | Kim, SM | Choe, Y | Choi, JH
Citation
Journal of cardiovascular computed tomography, 14(4). : 322-329, 2019
Journal Title
Journal of cardiovascular computed tomography
ISSN
1934-59251876-861X
Abstract
AIMS: The burden of coronary artery disease has been assessed by various semi-quantitative angiographic scores, which are frequently different each other. A non-invasive and quantitative modality may substitute angiographic sores for prognostic implication and decision of revascularization strategy. We compared fractional myocardial mass (FMM) with angiographic scores for predicting myocardial ischemia.
METHODS: In this multicenter registry, 411 patients who underwent coronary computed tomography angiography (CCTA) were followed by invasive coronary angiography and fractional flow reserve (FFR) measurement. CCTA-derived %FMM with diameter stenosis>/=70% (%FMM-70) or >/=50% (%FMM-50) were compared with 9 angiographic scores (APPROACH, Duke Jeopardy, BARI, CASS, SYNTAX, Jenkins, BCIS-1, Leaman, Modified Duke) and were tested regarding their performance for predicting FFRRESULTS: The performance of %FMM-70 and %FMM-50 were similar to most angiographic scores (%FMM-70, c-statistics = 0.74: %FMM-50, 0.73: angiographic scores, 0.68-0.77). The frequency of FFR/=36.3% and >/=8.7%, respectively. Using these cutoffs, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of %FMM-50 were 81%, 55%, 3%, 67%, 71%, and of %FMM-70 were 67%, 78%, 82%, 61%, 71%.
CONCLUSION: %FMM was comparable to angiographic scores for prediction of functional stenosis defined by FFR
Keywords
MeSH

DOI
10.1016/j.jcct.2019.11.001
PMID
31786052
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Ajou Authors
임, 홍석
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