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Indoor radon exposure increases tumor mutation burden in never-smoker patients with lung adenocarcinoma

Lim, SM | Choi, JW | Hong, MH | Jung, D | Lee, CY | Park, SY | Shim, HS | Sheen, S  | Kwak, KI | Kang, DR | Cho, BC | Kim, HR
Lung cancer (Amsterdam, Netherlands), 131. : 139-146, 2019
Journal Title
Lung cancer (Amsterdam, Netherlands)
OBJECTIVES: Radon, a natural radiation, is the leading environmental cause of lung cancer in never-smokers. However, the radon exposure impact on the mutational landscape and tumor mutation burden (TMB) of lung cancer in never-smokers has not been explored. The aim of this study was to investigate the mutational landscape of lung adenocarcinoma in never-smokers who were exposed to various degrees of residential radon.
MATERIALS AND METHODS: To investigate the effect of indoor radon exposure, we estimated the cumulative exposure to indoor radon in each house of patients with lung cancer with a never-smoking history. Patients with at least 2 year-duration of residence before the diagnosis of lung adenocarcinoma were included. Patients were subgrouped based on the median radon exposure level (48 Bq/m(3)): radon-high vs. radon-low and targeted sequencing of tumor and matched blood were performed in all patients.
RESULTS: Among 41 patients with lung adenocarcinoma, the TMB was significantly higher in the radon-high group than it was in the radon-low group (mean 4.94 vs. 2.6 mutations/Mb, P = 0.01). The recurrence rates between radon-high and radon-low group did not differ significantly. Mutational signatures of radon-high tumors showed features associated with inactivity of the base excision repair and DNA replication machineries. The analysis of tumor evolutionary trajectories also suggested a series of mutagenesis induced by radon exposure. In addition, radon-high tumors revealed a significant protein-protein interaction of genes involved in DNA damage and repair (P < 0.001).
CONCLUSIONS: Indoor radon exposure increased the TMB in never-smoker patients with lung adenocarcinoma and their mutational signature was associated with defective DNA mismatch repair.

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Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
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신, 승수
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