0 11

Cited 0 times in

Association of hyperuricemia and pulmonary hypertension: A systematic review and meta-analysis

Authors
Uk Kang, T; Park, KY; Kim, HJ; Ahn, HS; Yim, SY; Jun, JB
Citation
Modern rheumatology, 29(6). : 1031-1041, 2019
Journal Title
Modern rheumatology
ISSN
1439-75951439-7609
Abstract
OBJECTIVES: To investigate the association of hyperuricemia with pulmonary hypertension (PH) in term of subsequent development, severity, and prognosis of PH.
METHODS: The authors systematically reviewed articles from databases and conducted meta-analyses as follows: (1) association of serum uric acid (UA) levels with the presence of PH: (2) association between serum UA levels and subsequent development of PH, in terms of odds ratio of the development of PH: and (3) association of serum UA levels with severity and prognosis of PH, in terms of pulmonary arterial pressure and hazard ratio of death.
RESULTS: Twenty-six studies published between 1999 and 2017 were included. The level of serum UA was higher in subjects with PH than subjects without PH and this finding was observed regardless of status of diuretics use or renal function. The odds ratio of the development of PH was 2.32 (95% CI, 1.05-5.15) in subjects with hyperuricemia. Pulmonary arterial pressure among subjects with PH was also higher in subjects with hyperuricemia than subjects with normouricemia. There was a 19% increased hazard ratio of death (95% CI, 1.06-1.33) among patients with PH who had hyperuricemia.
CONCLUSION: Hyperuricemia is associated with the subsequent development, worse severity and poor prognosis of PH.
Keywords
Pulmonary hypertensionhyperuricemiaprognosisuric acid
MeSH terms
FemaleHumansHypertension, Pulmonary / bloodHypertension, Pulmonary / complicationsHypertension, Pulmonary / epidemiology*Hyperuricemia / bloodHyperuricemia / complications*Hyperuricemia / epidemiologyMaleMiddle AgedOdds RatioPrognosisUric Acid / blood
DOI
10.1080/14397595.2018.1537555
PMID
30334638
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physical Medicine & Rehabilitation
AJOU Authors
임, 신영
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse