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Curcumin inhibits cancer-associated fibroblast-derived chemoresistance of gastric cancer through suppression of the JAK/STAT3 signaling pathway
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 허, 훈 | - |
| dc.contributor.author | 우, 종수 | - |
| dc.date.accessioned | 2021-01-06T02:34:36Z | - |
| dc.date.available | 2021-01-06T02:34:36Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/19222 | - |
| dc.description.abstract | 비공개 | - |
| dc.description.tableofcontents | I. INTRODUCTION 1
II. MATERIALS AND METHODS 3 1. Cell culture 3 2. Western blotting 3 3. Cell viability assay 4 4. Secretome and transcriptome analysis 4 5. Flow cytometry analysis 5 6. Xenograft mouse model 5 7. Immunohistochemical staining 6 8. Statistical analysis 7 III. RESULTS 8 1. Cancer-associated fibroblasts reduce chemoresistance to 5-FU in GC cell lines 8 2. Evaluating whether CAFs activate the JAK2/STAT3 signal transduction pathway in GC cell lines 11 3. Determining whether c urcumin inactivated CAFs-induced JAK2/STAT3 signal transduction pathway in GC cell lines 15 4. Curcumin improves the apoptotic effect of chemotherapy on GC cells under co-culture with CAFs 19 5. Combined treatment using curcumin and 5-FU can effectively inhibit tumor growth for CAFs-mixed xenograft tumors 22 IV. DISCUSSION 27 V. REFERENCES 30 국문요약 35 | - |
| dc.language.iso | en | - |
| dc.title | Curcumin inhibits cancer-associated fibroblast-derived chemoresistance of gastric cancer through suppression of the JAK/STAT3 signaling pathway | - |
| dc.title.alternative | 커큐민의 JAK/STAT3 신호 전달 경로의 억제를 통한 위암의 암 관련 섬유 아세포 유래 항암제 저항성 억제에 대한 연구 | - |
| dc.type | Thesis | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000029609 | - |
| dc.subject.keyword | Gastric cancer | - |
| dc.subject.keyword | Cancer-associated fibroblasts | - |
| dc.subject.keyword | Chemoresistance | - |
| dc.subject.keyword | JAK/STAT3 signal transduction pathway | - |
| dc.subject.keyword | Curcumin | - |
| dc.subject.keyword | 위암 | - |
| dc.subject.keyword | 암 관련 섬유아세포 | - |
| dc.subject.keyword | 항암제 저항성 | - |
| dc.subject.keyword | JAK/STAT3 신호 전달 경로 | - |
| dc.subject.keyword | 커큐민 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | 대학원 의생명과학과 | - |
| dc.contributor.affiliatedAuthor | 우, 종수 | - |
| dc.date.awarded | 2020 | - |
| dc.type.local | Theses | - |
| dc.citation.date | 2020 | - |
| dc.embargo.liftdate | 9999-12-31 | - |
| dc.embargo.terms | 9999-12-31 | - |
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- Theses > Graduate School of Biomedical Sciences > Master
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