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Genetic polymorphism of interferon-gamma, interferon-gamma receptor, and interferon regulatory factor-1 genes in patients with hepatitis B virus infection.

Cheong, JY; Cho, SW; Chung, SG; Lee, JA; Yeo, M; Wang, HJ; Lee, JE; Hahm, KB; Kim, JH
Biochemical genetics, 44(5-6):246-255, 2006
Journal Title
Biochemical genetics
The natural history of hepatitis B virus (HBV) infection is probably related to host immune factors. Interferon-gamma (IFN-gamma) plays significant roles in immune defense. This study was undertaken to investigate the association between HBV infection and single nucleotide polymorphisms (SNPs) of IFN-gamma, IFN-gamma receptor (IFNGR)-1 and 2, and interferon regulatory factor (IRF)-1 genes. Between March 2002 and December 2002, 614 Korean patients were enrolled in two different groups: an HBV clearance group (n = 201), who were hepatitis B surface antigen (HBsAg) negative with antibodies to HBsAg and hepatitis B core antigen, and an HBV persistence group (n = 413), who were repeatedly HBsAg positive. We assessed polymorphisms in the IFN-gamma gene at position +874, in the IFNGR-1 gene at positions -56 and +95, in the IFNGR-2 gene at the second position of codon 64 (Gln64Arg), and in the IRF-1 gene promoter (-410, -388), and the genotype distributions of the HBV clearance and persistence groups were compared. On the basis of unconditional logistic regression analysis with adjustment for age and sex, no statistically significant association with susceptibility to persistent HBV infection was observed with the IFN-gamma, IFNGR-1 and 2, and IRF-1 gene polymorphisms under the codominant, dominant, and recessive models.
MeSH terms
AdolescentAdultAgedBase SequenceDNA Primers/geneticsFemaleHepatitis B/genetics*Hepatitis B/immunology*Hepatitis B/virologyHumansInterferon Regulatory Factor-1/genetics*Interferon-gamma/genetics*KoreaMaleMiddle AgedModels, GeneticPolymorphism, Single NucleotideReceptors, Interferon/genetics*
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > Research Organization > Genomic Research Center for Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
AJOU Authors
정, 재연조, 성원여, 말희왕, 희정함, 기백김, 진홍
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