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Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast.
DC Field | Value | Language |
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dc.contributor.author | Kang, Y | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Lee, TH | - |
dc.contributor.author | Kim, TS | - |
dc.contributor.author | Jung, WH | - |
dc.contributor.author | Chung, HC | - |
dc.contributor.author | Park, BW | - |
dc.contributor.author | Sheen, SS | - |
dc.contributor.author | Han, JH | - |
dc.date.accessioned | 2010-11-15T05:01:54Z | - |
dc.date.available | 2010-11-15T05:01:54Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/199 | - |
dc.description.abstract | The proteolytic destruction of cyclin B is an important event during cell division. Cyclin B proteolysis is triggered by the anaphase-promoting complex. Therefore, cell cycle dysregulation due to anaphase-promoting complex loss contributes to cell transformation and human carcinogenesis. This study investigates anaphase-promoting complex7 expression in spindle cell breast tumors and also includes a comparison between the proliferation antigen Ki-67 and S-phase fraction. The average values of the anaphase-promoting complex7 and Ki-67 labeling indices increased in order from benign to malignant within the phyllodes tumor group, and the fibroadenoma and juvenile fibroadenoma exhibited lower levels of anaphase-promoting complex7 and Ki-67 expression than did the phyllodes tumor. The frequency of anaphase-promoting complex7-positive stromal cells correlated with Ki-67 expression in phyllodes tumor and in all of the examined breast tumors. The above results indicate that anaphase-promoting complex7 and Ki-67 are closely related to cell proliferation. In addition, phyllodes tumor can be differentiated from juvenile fibroadenoma with increased mitotic figures mimicking phyllodes tumor by anaphase-promoting complex7 and Ki-67 immunochemistry. Because anaphase-promoting complex7 is expressed at higher levels than is Ki-67, it may overcome the limitations of the Ki-67 labeling index with regard to the differentiation of benign phyllodes tumor from fibroadenoma. | - |
dc.format | text/plain | - |
dc.language.iso | en | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Breast Neoplasms | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroadenoma | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Ki-67 Antigen | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phyllodes Tumor | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | S Phase | - |
dc.subject.MESH | Ubiquitin-Protein Ligase Complexes | - |
dc.subject.MESH | Young Adult | - |
dc.title | Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast. | - |
dc.type | Article | - |
dc.identifier.pmid | 18789487 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0046-8177(08)00293-1 | - |
dc.contributor.affiliatedAuthor | 강, 엽 | - |
dc.contributor.affiliatedAuthor | 김, 장희 | - |
dc.contributor.affiliatedAuthor | 신, 승수 | - |
dc.contributor.affiliatedAuthor | 한, 재호 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.humpath.2008.04.023 | - |
dc.citation.title | Human pathology | - |
dc.citation.volume | 40 | - |
dc.citation.number | 1 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 98 | - |
dc.citation.endPage | 107 | - |
dc.identifier.bibliographicCitation | Human pathology, 40(1). : 98-107, 2009 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.relation.journalid | J000468177 | - |
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