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Differences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Behcet's Disease with Arthritis

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dc.contributor.authorIslam, SMS-
dc.contributor.authorKim, HA-
dc.contributor.authorChoi, B-
dc.contributor.authorJung, JY-
dc.contributor.authorLee, SM-
dc.contributor.authorSuh, CH-
dc.contributor.authorSohn, S-
dc.date.accessioned2022-01-14T05:18:03Z-
dc.date.available2022-01-14T05:18:03Z-
dc.date.issued2019-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/20043-
dc.description.abstractIt has been reported Human Leukocyte Antigen (HLA) gene polymorphism is a risk factor for the development of Behcet's disease (BD). In this study, the association of HLA class II subtypes HLA-DP, DQ, DR, and T cell subsets in BD patients with arthritis was evaluated. Frequencies of HLA-DP, DQ, DR positive cells, and T cell subsets in peripheral blood leukocytes (PBL) were measured by flow cytometric analysis in BD, and compared to rheumatoid arthritis as disease controls and healthy controls. Frequencies of HLA-DQ were significantly decreased in whole PBL and granulocytes of BD active patients as compared to healthy controls. In monocytes populations, proportions of HLA-DR positive cells were significantly increased in BD active patients as compared to healthy controls. Proportions of CD4+CCR7+ and CD8+CCR7+ cells were significantly higher in BD active patients than in BD inactive in whole PBL. Frequencies of CD4+CD62L- and CD8+CD62L- cells in lymphocytes were significantly decreased in active BD than those in inactive BD. There were also correlations between disease activity markers and T cell subsets. Our results revealed HLA-DP, DQ, and DR expressing cell frequencies and several T cell subsets were significantly correlated with BD arthritis symptoms.-
dc.subject.MESHAdult-
dc.subject.MESHArthritis, Rheumatoid / immunology-
dc.subject.MESHBehcet Syndrome / immunology-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Variation-
dc.subject.MESHHLA-D Antigens / metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHT-Lymphocyte Subsets / immunology-
dc.titleDifferences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Behcet's Disease with Arthritis-
dc.typeArticle-
dc.identifier.pmid31614573-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829274/-
dc.subject.keywordBehçet’s disease-
dc.subject.keywordHLA-DP-
dc.subject.keywordHLA-DQ-
dc.subject.keywordHLA-DR-
dc.subject.keywordarthritis-
dc.subject.keywordinflammation-
dc.contributor.affiliatedAuthorKim, HA-
dc.contributor.affiliatedAuthorJung, JY-
dc.contributor.affiliatedAuthorSuh, CH-
dc.contributor.affiliatedAuthorSohn, S-
dc.type.localJournal Papers-
dc.identifier.doi10.3390/ijms20205044-
dc.citation.titleInternational journal of molecular sciences-
dc.citation.volume20-
dc.citation.number20-
dc.citation.date2019-
dc.citation.startPage5044-
dc.citation.endPage5044-
dc.identifier.bibliographicCitationInternational journal of molecular sciences, 20(20). : 5044-5044, 2019-
dc.identifier.eissn1422-0067-
dc.relation.journalidJ014220067-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
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