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Lipid-Core Plaque Assessed by Near-Infrared Spectroscopy and Procedure Related Microvascular Injury

Yang, HM  | Yoon, MH  | Lim, HS  | Seo, KW  | Choi, BJ  | Choi, SY  | Hwang, GS  | Tahk, SJ
Korean circulation journal, 49(11). : 1010-1018, 2019
Journal Title
Korean circulation journal
BACKGROUND AND OBJECTIVES: Microvascular damage due to distal embolization during percutaneous coronary intervention (PCI) is an important cause of periprocedural myocardial infarction. We assessed the lipid-core plaque using near-infrared spectroscopy (NIRS) and microvascular dysfunction invasively with the index of microcirculatory resistance (IMR) and evaluated their relationship.
METHODS: This study is pilot retrospective observational study. We analyzed 39 patients who performed NIRS before and after PCI, while fractional flow reserve, thermo-dilution coronary flow reserve (CFR) and IMR were measured after PCI. The maximum value of lipid core burden index (LCBI) for any of the 4-mm segments at the culprit lesion (culprit LCBI4mm) was calculated at the culprit lesion. We divided the patients into 2 groups using a cutoff of culprit LCBI4mm >/=500.
RESULTS: Mean pre-PCI LCBI was 333+/-196 and mean post-PCI IMR was 20+/-14 U. Post-PCI IMR was higher (15.6+/-7.3 vs. 42.6+/-17.6 U, p<0.001) and post-PCI CFR was lower (3.7+/-2.2 vs. 2.1+/-1.0, p=0.029) in the high LCBI group. Pre-PCI LCBI was positively correlated with post-PCI IMR (rho=0.358, p=0.025) and negatively correlated with post-PCI CFR (rho=-0.494, p=0.001). The incidence of microvascular dysfunction (IMR >/=25 U) was higher in the high LCBI group (9.4% vs. 85.7%, p<0.001). However, there were no significant differences in the incidences of creatine Kinase-MB (9.4% vs. 14.3%, p=0.563) and troponin-I elevation (12.5% vs. 14.3%, p=1.000).
CONCLUSIONS: A large lipid-core plaque at the 'culprit' lesion is observed higher incidence of post-PCI microvascular dysfunction after PCI. Prospective study with adequate subject numbers will be needed.

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Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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서, 경우  |  양, 형모  |  윤, 명호  |  임, 홍석  |  최, 병주  |  최, 소연  |  탁, 승제  |  황, 교승
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