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Natural course of fatty liver in 36,195 South Korean adults

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dc.contributor.authorSung, KC-
dc.contributor.authorLee, MY-
dc.contributor.authorLee, JY-
dc.contributor.authorLee, SH-
dc.contributor.authorKim, YB-
dc.contributor.authorSong, WJ-
dc.contributor.authorHuh, JH-
dc.contributor.authorPark, JS-
dc.contributor.authorShin, JH-
dc.contributor.authorSeo, MH-
dc.contributor.authorKim, SH-
dc.contributor.authorKim, SH-
dc.date.accessioned2022-01-14T05:19:08Z-
dc.date.available2022-01-14T05:19:08Z-
dc.date.issued2019-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/20098-
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease, and yet the natural course remains unclear. Study population included 36,195 individuals who participated in a health-screening program and diagnosed with fatty liver by abdominal ultrasound. Participants were provided written information regarding fatty liver and advised to make lifestyle changes. Ultrasound was repeated after at least 6 months. After a mean follow up of 4.9 years (+/-3.4), 19.6% resolved their fatty liver. Individuals who resolved were more likely female (22.9% vs. 12.3%), thinner (body mass index [BMI], 25.2 +/- 2.7 vs. 26 +/- 2.7), and with lower HOMA-IR (1.4 vs. 1.7) (P .70.001). Decrease in BMI predicted resolution of fatty liver with 42% of those in the top quartile of BMI decline resolving compared with 5.7% in the lowest quartile (odds ratio [OR] (95% confidence interval [CI]) 15.65 (14.13-17.34), P < 0.001)). Baseline HOMA-IR also predicted resolution with those in the top quartile (most insulin resistant) being least likely to resolve (12%) vs. those in the lowest quartile (25%) (OR 0.36 [0.31-0.42], P < 0.001). Fatty liver disease is persistent. Individuals with higher degree of insulin resistance are also the most likely to have persistent steatosis at follow up.-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers-
dc.subject.MESHDisease Progression-
dc.subject.MESHFatty Liver-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPublic Health Surveillance-
dc.subject.MESHRepublic of Korea-
dc.titleNatural course of fatty liver in 36,195 South Korean adults-
dc.typeArticle-
dc.identifier.pmid31308382-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629682/-
dc.contributor.affiliatedAuthorPark, JS-
dc.type.localJournal Papers-
dc.identifier.doi10.1038/s41598-019-44738-7-
dc.citation.titleScientific reports-
dc.citation.volume9-
dc.citation.number1-
dc.citation.date2019-
dc.citation.startPage9062-
dc.citation.endPage9062-
dc.identifier.bibliographicCitationScientific reports, 9(1). : 9062-9062, 2019-
dc.identifier.eissn2045-2322-
dc.relation.journalidJ020452322-
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Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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