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Multicenter Prospective Study of Laparoscopic Nissen Fundoplication for Gastroesophageal Reflux Disease in Korea

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dc.contributor.authorPark, S-
dc.contributor.authorPark, JM-
dc.contributor.authorKim, JJ-
dc.contributor.authorLee, IS-
dc.contributor.authorHan, SU-
dc.contributor.authorSeo, KW-
dc.contributor.authorKwon, JW-
dc.date.accessioned2022-01-14T05:19:45Z-
dc.date.available2022-01-14T05:19:45Z-
dc.date.issued2019-
dc.identifier.issn2093-0879-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/20122-
dc.description.abstractBACKGROUND/AIMS: This multicenter study aims to evaluate the effect and feasibility of anti-reflux surgery compared with medical treatment for gastroesophageal reflux disease (GERD).
METHODS: Patients with GERD who were undergoing medical treatment with proton pump inhibitors for more than 8 weeks and those who were scheduled to undergo anti-reflux surgery were enrolled. Efficacy of pre-operative medical treatment was evaluated retrospectively and effect of anti-reflux surgery was prospectively evaluated at 1 week and 3 months after surgery. Quality of life (QOL) was also investigated before and after surgery.
RESULTS: Between February and October 2018, 51 patients underwent laparoscopic Nissen fundoplication for treating GERD at 5 hospitals in Korea. Thirty-four patients (66.7%) showed poor proton pump inhibitor response. At 3 months after surgery, heartburn was completely resolved in 87.9% patients and partially improved in 9.1%. Acid regurgitation was completely resolved in 82.9% and partially improved in 11.4%. Atypical extraesophageal symptoms were completely controlled in 45.5% and partially controlled in 36.4%. GERD-related QOL scores at 1 week after surgery significantly improved compared with pre-operative scores. There was no difference in GERD-related QOL scores between 1 week and 3 months after surgery. General QOL measured with European QOL-5 dimensions and health-related QOL instrument with 8 items significantly improved after anti-reflux surgery. Satisfaction with treatment was significantly higher after surgery than before surgery (72.5% vs 11.8%, P < 0.001).
CONCLUSION: Anti-reflux surgery improved GERD symptoms and QOL in patients. Anti-reflux surgery is an effective treatment option compared with medical treatment for GERD patients selected for surgical treatment.
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dc.titleMulticenter Prospective Study of Laparoscopic Nissen Fundoplication for Gastroesophageal Reflux Disease in Korea-
dc.typeArticle-
dc.identifier.pmid31327221-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657928/-
dc.subject.keywordFundoplication-
dc.subject.keywordGastroesophageal reflux-
dc.subject.keywordLaparoscopy-
dc.subject.keywordQuality of life-
dc.contributor.affiliatedAuthorHan, SU-
dc.type.localJournal Papers-
dc.identifier.doi10.5056/jnm19059-
dc.citation.titleJournal of neurogastroenterology and motility-
dc.citation.volume25-
dc.citation.number3-
dc.citation.date2019-
dc.citation.startPage394-
dc.citation.endPage402-
dc.identifier.bibliographicCitationJournal of neurogastroenterology and motility, 25(3). : 394-402, 2019-
dc.identifier.eissn2093-0887-
dc.relation.journalidJ020930879-
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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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