38 102

Cited 0 times in

Genetic aspects of type 1 diabetes

Authors
Lee, HS  | Hwang, JS
Citation
Annals of pediatric endocrinology & metabolism, 24(3). : 143-148, 2019
Journal Title
Annals of pediatric endocrinology & metabolism
ISSN
2287-10122287-1292
Abstract
Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial role in development of T1DM. The human leukocyte antigen complex plays a key role in the pathogenesis of T1DM. Furthermore, genome-wide association studies and linkage analysis have recently made a significant contribution to current knowledge relative to the impact of genetics on T1DM development and progression. This review focuses on current knowledge of genetics as a pathogenesis for T1DM. It also discusses mechanisms by which genes influence the risk of developing T1DM as well as the clinical and research applications of genetic risk scores in T1DM.
Keywords
DOI
10.6065/apem.2019.24.3.143
PMID
31607106
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Ajou Authors
이, 해상  |  황, 진순
Full Text Link
Files in This Item:
31607106.pdfDownload
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse