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Thyrotoxic hypokalemic periodic paralysis due to Graves' disease in 2 adolescents

Authors
Roh, JG  | Park, KJ | Lee, HS  | Hwang, JS
Citation
Annals of pediatric endocrinology & metabolism, 24(2). : 133-136, 2019
Journal Title
Annals of pediatric endocrinology & metabolism
ISSN
2287-10122287-1292
Abstract
Thyrotoxic periodic paralysis (TPP) is a notable and potentially lethal complication of thyrotoxicosis, and Graves' disease is the most common cause of TPP. TPP is commonly reported in Asian males between 20-40 years of age, but it is rare in children and adolescents. We report 2 Korean adolescents (a 16-year-old male and a 14-year-old female) with episodes of TPP who were previously diagnosed with Graves' disease. These 2 patients presented with lower leg weakness in the morning after waking up. They were diagnosed with TPP-associated with thyrotoxicosis due to Graves' disease. After they were initially treated with potassium chloride and antithyroid drugs, muscle paralysis improved and an euthyroid state without muscle paralytic events was maintained during follow-up. Therefore, clinicians should consider TPP when patients have sudden paralysis and thyrotoxic symptoms such as goiter, tachycardia, and hypertension.
Keywords

DOI
10.6065/apem.2019.24.2.133
PMID
31261479
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Ajou Authors
노, 정기  |  이, 해상  |  황, 진순
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