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Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment

Authors
Son, SJ  | Park, B  | Choi, JW  | Roh, HW | Kim, NR | Sin, JE | Kim, H | Lim, HK | Hong, CH
Citation
Frontiers in psychiatry, 10. : 615-615, 2019
Journal Title
Frontiers in psychiatry
ISSN
1664-0640
Abstract
BACKGROUND: It has been suggested that maintaining the efficient organization of the brain's functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI).
METHODS: Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/amygdala (AMG)/hippocampus (HP)/parahippocampal gyrus (PHG) FC according to the different levels of resilience scale.
RESULTS: Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (P < 0.05, Bonferroni corrected), between the right inferior OFG and left PHG (P < 0.05, Bonferroni corrected), and between the right middle OFG and left PHG (false discovery rate < 0.05).
CONCLUSION: Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.
Keywords
DOI
10.3389/fpsyt.2019.00615
PMID
31555158
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Ajou Authors
박, 범희  |  손, 상준  |  최, 진욱  |  홍, 창형
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