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The long-term effects of rosiglitazone on serum lipid concentrations and body weight.

Authors
Shim, WS; Do, MY; Kim, SK; Kim, HJ; Hur, KY; Kang, ES; Ahn, CW; Lim, SK; Lee, HC; Cha, BS
Citation
Clinical endocrinology, 65(4):453-459, 2006
Journal Title
Clinical endocrinology
ISSN
0300-06641365-2265
Abstract
OBJECTIVE: Although rosiglitazone, an insulin sensitizer, is known to have beneficial effects on high density lipoprotein cholesterol (HDL-C) concentrations and low density lipoprotein (LDL) particle size, it has unwanted effects on total cholesterol (TC) and LDL cholesterol (LDL-C) concentrations and body weight in some short-term studies. The aim of this study was to evaluate the long-term effects of rosiglitazone on serum lipid levels and body weight.



DESIGN: Open labelled clinical study.



PATIENTS AND MEASUREMENTS: We prospectively evaluated fasting serum glucose, haemoglobin A(1c) (HbA(1c)), lipid profiles and body weight at baseline and every 3 months after the use of rosiglitazone (4 mg/day) for 18 months in 202 type 2 diabetic patients.



RESULTS: TC levels increased maximally at 3 months and decreased thereafter. However, overall, TC levels remained significantly higher at 18 months than those at baseline. LDL-C levels from the 3-month to the 12-month timepoint were significantly higher than those at baseline. However, after 15 months, LDL-C concentrations were not significantly different from basal LDL-C concentrations. HDL-C levels increased after the first 3 months and these levels were maintained. The increment of change in HDL-C was more prominent in patients with low basal HDL-C concentrations than in patients with high basal HDL-C concentrations. Body weight increased after the first 3 months and these levels were maintained.



CONCLUSIONS: HDL-C and body weight increased and remained elevated for the duration of the study. There was an initial increase in LDL-C but this attenuated and by the end of the study was not significantly elevated above baseline levels.
MeSH terms
AdultBlood Glucose/metabolismBody Mass IndexBody Weight*Cholesterol/bloodCholesterol, HDL/bloodCholesterol, LDL/bloodDiabetes Mellitus, Type 2/bloodDiabetes Mellitus, Type 2/drug therapy*FemaleHemoglobin A, Glycosylated/analysisHumansHypoglycemic Agents/therapeutic use*Insulin/bloodLipids/blood*MaleMiddle AgedProspective StudiesThiazolidinediones/therapeutic use*TimeTriglycerides/blood
DOI
10.1111/j.1365-2265.2006.02614.x
PMID
16984237
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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김, 혜진
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