Cited 0 times in Scipus Cited Count

Effects of a combined alendronate and calcitriol agent (Maxmarvil) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study.

DC Field Value Language
dc.contributor.authorRhee, Y-
dc.contributor.authorKang, M-
dc.contributor.authorMin, Y-
dc.contributor.authorByun, D-
dc.contributor.authorChung, Y-
dc.contributor.authorAhn, C-
dc.contributor.authorBaek, K-
dc.contributor.authorMok, J-
dc.contributor.authorKim, D-
dc.contributor.authorKim, H-
dc.contributor.authorKim, Y-
dc.contributor.authorMyoung, S-
dc.contributor.authorLim, SK-
dc.date.accessioned2011-03-30T01:35:14Z-
dc.date.available2011-03-30T01:35:14Z-
dc.date.issued2006-
dc.identifier.issn0937-941X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2051-
dc.description.abstractINTRODUCTION: A randomized, double-blind, prospective, 24-week clinical trial was performed to evaluate the effects of a combinative agent, Maxmarvil, of calcitriol (0.5 mug) and alendronate (5 mg) on bone metabolism in postmenopausal women.



METHODS: A total of 217 postmenopausal women with osteoporosis were enrolled; 199 patients were randomly assigned to one of two treatment groups (Maxmarvil group or alfacalcidol group). None of the patients were vitamin-D-deficient, as assessed by serum 25-hydroxyvitamin D (25(OH)D), nor had they received any drugs affecting bone metabolism before enrollment. Bone mineral densities (BMD) of L1-L4 and the femur were measured by dual-energy X-ray absorptiometry (DXA) at the initial assessment and after 6 months of treatment. Serum biochemical assays, including serum calcium, 24-h urinary calcium excretion, and bone turnover markers (both bone-specific alkaline phosphatase [bsALP] and urine N-telopeptide [NTx]), were performed at the baseline and after 3 and 6 months of treatment.



RESULTS: In the Maxmarvil group, the BMD of the lumbar spine increased up to 2.42+/-0.5% from the baseline after 6 months (p<0.05). On the other hand, the change in BMD in the alfacalcidol group was 0.28+/-0.5% after 6 months. There was no significant difference in femoral BMD between the two groups. The levels of bsALP and NTx were significantly lower in the Maxmarvil group than in the alfacalcidol group (-22.04+/-3.9% vs. -11.42+/-2.8% [p<0.05] and -25.46+/-5.2% vs. 1.24+/-6.2% [p<0.001], respectively). Interestingly, there was a significantly smaller amount of 24-h urinary calcium in the Maxmarvil group (p<0.05).



CONCLUSIONS: Our study demonstrates that a combination of calcitriol and alendronate is quite effective in preventing bone loss, with the advantage of lesser hypercalciuric effect of calcitriol in the postmenopausal osteoporotic women.
-
dc.language.isoen-
dc.subject.MESHAlendronate-
dc.subject.MESHAlkaline Phosphatase-
dc.subject.MESHBiological Markers-
dc.subject.MESHBone Density-
dc.subject.MESHBone Density Conservation Agents-
dc.subject.MESHCalcitriol-
dc.subject.MESHCollagen Type I-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHDrug Combinations-
dc.subject.MESHFemale-
dc.subject.MESHFemur-
dc.subject.MESHHumans-
dc.subject.MESHHydroxycholecalciferols-
dc.subject.MESHKorea-
dc.subject.MESHLumbar Vertebrae-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsteoporosis, Postmenopausal-
dc.subject.MESHPeptides-
dc.subject.MESHTreatment Outcome-
dc.titleEffects of a combined alendronate and calcitriol agent (Maxmarvil) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study.-
dc.typeArticle-
dc.identifier.pmid17019520-
dc.contributor.affiliatedAuthor정, 윤석-
dc.contributor.affiliatedAuthor김, 대중-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00198-006-0200-4-
dc.citation.titleOsteoporosis international-
dc.citation.volume17-
dc.citation.number12-
dc.citation.date2006-
dc.citation.startPage1801-
dc.citation.endPage1807-
dc.identifier.bibliographicCitationOsteoporosis international, 17(12). : 1801-1807, 2006-
dc.identifier.eissn1433-2965-
dc.relation.journalidJ00937941X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse