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Concurrent chemoradiotherapy in patients with nasopharyngeal cancer: prognostic significance of low expression of bax.

Authors
Kang, SY; Oh, YT; Han, JH; Choi, JH; Lim, HY; Kim, HI; Lee, HW; Jang, JH; Park, JS; Kim, HC; Kang, S; Chun, M; Kim, CH; Joo, HJ
Citation
Neoplasma, 53(5):450-456, 2006
Journal Title
Neoplasma
ISSN
0028-26851338-4317
Abstract
A randomized trial has demonstrated that concurrent chemoradiotherapy (CRT) is superior to radiotherapy (RT) alone in locally advanced nasopharyngeal cancer (NPC). Our study comprise 35 patients with locally advanced NPC (stage I: 1, II: 12, III: 7, IV: 15) with 1 cycle of induction chemotherapy (5-fluorouracil 1,000 mg/m(2)/day and cisplatin 20 mg/m(2)/day, days 1- 4) followed by concurrent CRT starting on day 22. Concurrent CRT consisted of RT (70 Gy/35 fractions for 7 weeks) with cisplatin 20 mg/m(2)/day for 4 days on weeks 1, 4, 7 of RT. Complete response (CR) was achieved in 33 patients (94%). Four-year progression-free survival (PFS) and overall survival (OS) of all patients were 57% and 65%, respectively. In analysis of prognostic factors, low expression of bax was the most significant independent predictor of poor prognosis in both PFS (p=0.002) and OS (p=0.008). In conclusion, the outcome of patients treated with this combined therapeutical modality appears to be comparable with that of Intergroup 0099 trial with high CR rate. Low expression of bax was significantly associated with poor PFS and OS.
MeSH terms
AdultAntineoplastic Agents/therapeutic use*Cisplatin/therapeutic useCombined Modality TherapyFemaleFluorouracil/therapeutic useHumansMaleMiddle AgedNasopharyngeal Neoplasms/drug therapy*Nasopharyngeal Neoplasms/mortalityNasopharyngeal Neoplasms/radiotherapy*PrognosisSurvival AnalysisTumor Markers, Biological/analysisbcl-2-Associated X Protein/biosynthesis*
PMID
17013542
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
AJOU Authors
강석윤오영택한재호최진혁이현우장준호박준성김효철강승희전미선김철호주희재
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