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Unresponsiveness of C-reactive protein in the non-infectious inflammation of systemic lupus erythematosus is associated with interleukin 6.

Authors
Suh, CH; Chun, HY; Ye, YM; Park, HS
Citation
Clinical immunology (Orlando, Fla.), 119(3):291-296, 2006
Journal Title
Clinical immunology (Orlando, Fla.)
ISSN
1521-66161521-7035
Abstract
C-reactive protein (CRP) response is abnormal to a non-infectious inflammation in systemic lupus erythematosus (SLE). We evaluated the role of cytokines in this CRP unresponsiveness. The sera of 138 SLE patients and 71 rheumatoid arthritis patients were collected prospectively. SLE with infection had higher WBC count, ESR, CRP and C4 levels than those without infection. IL-6, IL-10 and IFN-gamma levels were higher in SLE with infection than SLE without infection. In SLE with infection, the CRP was correlated with the IL-6 (r = 0.77, P < 0.001) but not correlated with IL-10 and IFN-gamma. These data suggest that IL-6 may have a role in the unresponsiveness of CRP to a non-infectious inflammation of SLE.
MeSH terms
AdolescentAdultC-Reactive Protein/analysis*Complement C4/analysisCytokines/blood*FemaleHumansInfection/bloodInfection/immunologyInflammation/bloodLeukocyte CountLupus Erythematosus, Systemic/blood*Lupus Erythematosus, Systemic/immunologyMaleMiddle Aged
DOI
10.1016/j.clim.2005.11.006
PMID
16406714
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
서, 창희예, 영민박, 해심
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