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Relationship between neurokinin 2 receptor gene polymorphisms and serum vascular endothelial growth factor levels in patients with toluene diisocyanate-induced asthma.

Ye, YM; Kang, YM; Kim, SH; Kim, CW; Kim, HR; Hong, CS; Park, CS; Kim, HM; Nahm, DH; Park, HS
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 36(9):1153-1160, 2006
Journal Title
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
BACKGROUND: Among the various pathogenic mechanisms of toluene diisocyanate (TDI)-induced asthma, a contribution from neurogenic inflammation has been suggested.

OBJECTIVE: To evaluate neurokinin 2 receptor (NK2R) gene polymorphisms in association with the clinical phenotype of TDI-induced asthma, 70 TDI-induced occupational asthma (TDI-OA)patients, 59 asymptomatic exposed controls (AEC), and 93 unexposed healthy controls (NC) were enrolled in the study.

METHODS: Two single-nucleotide polymorphisms (SNPs) of NK2R, 7853G>A (Gly231Glu) and 11 424G>A (Arg375His), were genotyped using a single base extension method. The levels of PC20 methacholine, specific IgE and IgG to TDI-human serum albumin conjugate, and serum vascular endothelial growth factor (VEGF), matrix metalloproteinase-9, and TGF-beta1 were compared according to the NK2R genotypes of the subjects with TDI-OA and AEC.

RESULTS: No significant differences in allele, genotype, or haplotype frequencies of these two SNPs were noted among the three groups (P>0.05, respectively). Moreover, subjects with the NK2R 7853GG genotype had higher serum VEGF levels than those with GA or AA among the TDI-exposed workers (P=0.040).

CONCLUSION: The NK2R 7853GG genotype may contribute to increased serum VEGF levels, which result in airway inflammation after TDI exposure.
MeSH terms
AdultAsthma/bloodAsthma/chemically inducedAsthma/genetics*FemaleForced Expiratory VolumeGene Frequency/geneticsGenetic Predisposition to Disease/geneticsGenotypeHaplotypes/geneticsHumansImmunoglobulin E/bloodMaleMiddle AgedOccupational Diseases/bloodOccupational Diseases/chemically inducedOccupational Diseases/genetics*Polymorphism, Single Nucleotide/genetics*Receptors, Neurokinin-2/genetics*Toluene 2,4-Diisocyanate/toxicity*Vascular Endothelial Growth Factor A/blood*
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
예, 영민김, 승현남, 동호박, 해심
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