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Association of TNF-alpha genetic polymorphism with HLA DPB1*0301.
DC Field | Value | Language |
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dc.contributor.author | Kim, SH | - |
dc.contributor.author | Ye, YM | - |
dc.contributor.author | Lee, SK | - |
dc.contributor.author | Choi, JH | - |
dc.contributor.author | Holloway, JW | - |
dc.contributor.author | Park, CS | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2011-03-31T04:55:57Z | - |
dc.date.available | 2011-03-31T04:55:57Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/2084 | - |
dc.description.abstract | BACKGROUND: We speculated TNF-alpha can be one of candidate gene for aspirin-intolerant asthma (AIA) because TNF-alpha is pro-inflammatory cytokine and known to be increased level in asthmatic airways. In addition, genetic interaction between TNF-alpha and human antigen leucocyte (HLA) DPB1*0301, which is a strong genetic marker for AIA, was examined for its close location within chromosome 6.
METHOD: To investigate genetic association of TNF-alpha with an AIA phenotype, three study groups (163 patients with AIA, 197 patients with aspirin-tolerant asthma (ATA), 257 normal control subjects) were enrolled. Single nucleotide polymorphisms (SNPs) were genotyped using a single-base extension method and HLA DPB1 genotyping was determined by high-throughput sequencing method. RESULTS: All five SNPs of TNF-alpha were tested; there were no significant differences in allele and genotype frequencies among the three groups. However, significant association between TNF-alpha-308G>A polymorphism and atopy status was noted (P<0.05). Gene to gene interaction between TNF-alpha-1031T>C (or -863C>A or -857C>A) and HLA DPB1*0301could synergistically increase the susceptibility to AIA with odds ratio (OR) to 7.738 (or OR=8.184 for -863C>A, OR=7.500 for -857C>T, P<0.001, respectively). CONCLUSION: TNF-alpha promoter polymorphism may significantly increase susceptibility to AIA by gene-to-gene interaction with HLA DPB1*0301. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal | - |
dc.subject.MESH | Aspirin | - |
dc.subject.MESH | Asthma | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genes, X-Linked | - |
dc.subject.MESH | Genetic Markers | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | HLA-DP Antigens | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha | - |
dc.title | Association of TNF-alpha genetic polymorphism with HLA DPB1*0301. | - |
dc.type | Article | - |
dc.identifier.pmid | 17014432 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2006&volume=36&issue=10&spage=1247 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 예, 영민 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/j.1365-2222.2006.02567.x | - |
dc.citation.title | Clinical and experimental allergy | - |
dc.citation.volume | 36 | - |
dc.citation.number | 10 | - |
dc.citation.date | 2006 | - |
dc.citation.startPage | 1247 | - |
dc.citation.endPage | 1253 | - |
dc.identifier.bibliographicCitation | Clinical and experimental allergy, 36(10). : 1247-1253, 2006 | - |
dc.identifier.eissn | 1365-2222 | - |
dc.relation.journalid | J009547894 | - |
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