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Changes of serum cytokines after the long term immunotherapy with Japanese hop pollen extracts.
DC Field | Value | Language |
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dc.contributor.author | Ye, YM | - |
dc.contributor.author | Lee, SK | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Nahm, DH | - |
dc.contributor.author | Suh, CH | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2011-03-31T05:21:28Z | - |
dc.date.available | 2011-03-31T05:21:28Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/2087 | - |
dc.description.abstract | Japanese hop (Hop J) pollen has been considered as one of the major causative pollen allergens in the autumn season. We developed a new Hop J immunotherapy extract in collaboration with Allergopharma (Reinbeck, Germany) and investigated immunologic mechanisms during 3 yr immunotherapy. Twenty patients (13 asthma with rhinitis and 7 hay fever) were enrolled from Ajou University Hospital. Sera were collected before, 1 yr, and 3 yr after the immunotherapy. Changes of serum specific IgE, IgG1, and IgG4 levels to Hop J pollen extracts and serum IL-10, IL-12, TGF-beta1 and soluble CD23 levels were monitored by ELISA. Skin reactivity and airway hyper-responsiveness to methacholine were improved during the study period. Specific IgG1 increased at 1 yr then decreased again at 3 yr, and specific IgG4 levels increased progressively (p<0.05, respectively), whereas total and specific IgE levels showed variable responses with no statistical significance. IL-10, TGF-beta1 and soluble CD23 level began to decrease during first year and then further decreased during next two years with statistical significances. (p<0.05, respectively). In conclusion, these findings suggested the favorable effect of long term immunotherapy with Hop J pollen extracts can be explained by lowered IgE affinity and generation of specific IgG4, which may be mediated by IL-10 and TGF-beta1. | - |
dc.language.iso | en | - |
dc.subject.MESH | Bronchial Hyperreactivity | - |
dc.subject.MESH | Cytokines | - |
dc.subject.MESH | Desensitization, Immunologic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E | - |
dc.subject.MESH | Immunoglobulin G | - |
dc.subject.MESH | Interleukin-10 | - |
dc.subject.MESH | Poaceae | - |
dc.subject.MESH | Pollen | - |
dc.subject.MESH | Receptors, IgE | - |
dc.subject.MESH | Transforming Growth Factor beta | - |
dc.title | Changes of serum cytokines after the long term immunotherapy with Japanese hop pollen extracts. | - |
dc.type | Article | - |
dc.identifier.pmid | 17043410 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721987/ | - |
dc.contributor.affiliatedAuthor | 예, 영민 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 남, 동호 | - |
dc.contributor.affiliatedAuthor | 서, 창희 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.3346/jkms.2006.21.5.805 | - |
dc.citation.title | Journal of Korean medical science | - |
dc.citation.volume | 21 | - |
dc.citation.number | 5 | - |
dc.citation.date | 2006 | - |
dc.citation.startPage | 805 | - |
dc.citation.endPage | 810 | - |
dc.identifier.bibliographicCitation | Journal of Korean medical science, 21(5). : 805-810, 2006 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.relation.journalid | J010118934 | - |
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