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Genetic markers for differentiating aspirin-hypersensitivity.

Authors
Kim, SH; Park, HS
Citation
Yonsei medical journal, 47(1):15-21, 2006
Journal Title
Yonsei medical journal
ISSN
0513-57961976-2437
Abstract
Aspirin-induced asthma (AIA) and aspirin-induced urticaria/ angioedema (AIU) are two major aspirin-related allergies. We summarize recent findings related to their molecular genetic mechanisms in order to identify genetic susceptibility markers for differentiating AIU and AIA. The overproduction of cysteinyl leukotriene has been suggested as a mechanism in both AIU and AIA. Increased expression of CYSLTR1 with CYLSTR1 and CYSLTR2 polymorphisms are new findings in AIA, while the ALOX5 promoter polymorphism has been noted in AIU. An HLA study suggested that DPB1*0301 is a strong genetic marker for AIA, and that HLA DRB1*1302 and DQB1*0609 are markers for AIU susceptibility. Several single nucleotide polymorphisms (SNPs) in the promoters of EP2, TBX21, COX-2, Fc epsilon RIbeta, and TBXA2R were associated with AIA, while an Fc epsilon RIalpha promoter polymorphism was associated with AIU. The functional studies of the key genes involved in AIA and AIU are summarized. The identification and functional study of genetic markers for AIA and AIU susceptibility would further elucidate the pathogenic mechanisms and facilitate the development of early diagnostic markers to establish therapeutic targets.
MeSH terms
AllelesAnti-Inflammatory Agents, Non-Steroidal/adverse effects*Aspirin/adverse effects*Asthma/chemically inducedAsthma/diagnosisAsthma/geneticsDrug Hypersensitivity/diagnosisDrug Hypersensitivity/drug therapyDrug Hypersensitivity/genetics*Genetic MarkersGenetic Predisposition to DiseaseHumansKoreaPolymorphism, Single NucleotideUrticaria/chemically inducedUrticaria/diagnosisUrticaria/genetics
DOI
10.3349/ymj.2006.47.1.15
PMID
16502481
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김승현박해심
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