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Tissue engineering of heart valves in vivo using bone marrow-derived cells.

Authors
Kim, SS; Lim, SH; Hong, YS; Cho, SW; Ryu, JH; Chang, BC; Choi, CY; Kim, BS
Citation
Artificial organs, 30(7):554-557, 2006
Journal Title
Artificial organs
ISSN
0160-564X1525-1594
Abstract
In this study, we tissue-engineered heart valves in vivo using autologous bone marrow-derived cells (BMCs). Canine BMCs were differentiated into endothelial cell (EC)-like cells and myofibroblast (MF)-like cells. Decellularized porcine pulmonary valves were seeded with BMCs and implanted to abdominal aorta and pulmonary valve of bone marrow donor dogs. Histological examination of the explants identified the regeneration of valvular structures expressing CD31 and smooth muscle alpha-actin, indicating the presence of EC-like and MF-like cells in the grafts at 3 and 1 week, respectively, after implantation. Fluorescent microscopic examinations identified the presence of fluorescently labeled cells in the explants, indicating that the implanted BMCs survived and participated in the heart valve reconstitution. This study reports, for the first time, on tissue engineering of heart valve in vivo using BMCs.
MeSH terms
AnimalsBone Marrow Cells/cytology*Cell Differentiation*DogsHeart Valves*Implants, ExperimentalTissue Engineering/methods*
DOI
10.1111/j.1525-1594.2006.00258.x
PMID
16836737
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Thoracic & Cardiovascular Surgery
AJOU Authors
임, 상현
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