Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with heterogeneous clinical manifestations mediated by immune dysregulation. In this study, 24 free fatty acids (FFAs) alterations in plasma of 41 SLE patients were investigated using gas chromatography mass spectrometry (GC MS) in selected ion monitoring modes as their tert butyldimethylsilyl derivatives, compared with 41 healthy controls (HC). The results of the Student’s t test on the control mean of SLE group showed that patients with SLE group and HC had distinguishable difference in 11 of 24 FFAs profile. Among 11 changed levels of FFAs, 4 levels of FFAs were significantly increased and 7 levels of FFAs were decreased in SLE patients. In the partial correlation with FFAs profiles and disease activity markers in SLE, several metabolic markers were correlated with disease activity of SLE. Our results provide a comprehensive understanding of relationship between that metabolomics and disease activity markers of SLE. Thus, this approach has a promising potential in the discovery of metabolic clinical markers for the SLE.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :10,643,903
Total Download :4,380,844
Today View :286
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.