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Jak3-dependent differentiation in the spinal nestin-positive progenitors

Authors
Barua, Sumit | Chung, Jee-In | Kim, A Young | Lee, Soo-Yeon | Baik. Eun Joo
Department
Department of Physiology, Ajou University School of Medicine  | Chronic Inflammatory Disease Research Center, Ajou Research Institute for Innovative Medicine
Abstract
During spinal cord development, endogenous progenitors expressing nestin can migrate into the target and differentiate into neuron and other glial cells. Microglial cells also can be derived from nestin+ progenitor cells, even in the adult brain. In E13.5 spinal cell cultures with growth factors, developing neurons could not survive after several days, and also the significant portion of nestin expressing cells transformed into Iba1+ microglial cells, which exponentially increased after 5 days. However, Jak3 inhibition significantly increased MAP2+ neurons and the Tuj1 + growing neurites into the lesion site with little microglial activation. The transcription factors responsible for microgliogenesis, and microglial migration and phagocytosis, such as PU.1, Irf8, CD11b, and Runx1 were strongly regulated by Jak3 signaling. These result indicated that neuronal and microglial cell differentiation were regulated primarily by Jak3 signaling.
Appears in Collections:
Poster > School of Medicine / Graduate School of Medicine > Department of Physiology
Poster > Research Organization > Chronic Inflammatory Disease Research Center
Ajou Authors
대학, 생리학교실  |  연구기관, 만성염증질환연구센터
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