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Dysregulated Expression of Mitoribosomal Proteins (MRPs) Promotes Invasiveness and Induces Suppressive Immune Response in Hepatocellular Carcinoma (HCC)

Authors
Kwon, So Mee | Lee, Young-Kyoung | Hong, Sun-Mi | Min, Seongki | Woo, Hyun Goo | Yoon, Gyesoon
Department
Department of Physiology, Ajou University School of Medicine  | Department of Biochemistry & Molecular Biology, Ajou University School of Medicine  | Department of Biomedical Sciences, Graduate School of Ajou University
Abstract
Mitochondrial ribosomes (mitoribosomes) are the specialized translational machinery for mitochondrial DNA (mtDNA) genes, exclusively encoding 13 subunits of the oxidative phosphorylation system. MRPs, the nuclear-encoded macromolecular complex, are the main components of mitoribosomes and associated with diverse diseases including cancer. Here, we have identified that gene-signature representing MRPs defects (MRP_defect) by performing gene expression profiling of MRPs using The Cancer Genome Atlas (TCGA) HCC cohort and show its prognostic significance by performing survival analysis. Based on the MRP_defect, we divide tumor tissues into two groups: MRPs defects (D) and without MRPs defect (ND). We found that genes related to immune response, cell cycle and epithelial-mesenchymal transition (EMT) were up-regulated, while those related to the mitochondrial metabolic and biosynthetic function were down-regulated in D group. Furthermore, we observed differential enrichment of suppressive immune or anti-tumor immune cells in the microenvironment between D and ND group, implying that MRP defects may promote immunosuppression and evasion from immune surveillance. Our findings suggest that the MRPs defects assessment may provide to survey liver tumor immunity for immune based therapy.
Appears in Collections:
Poster > School of Medicine / Graduate School of Medicine > Department of Physiology
Poster > School of Medicine / Graduate School of Medicine > Department of Biochemistry & Molecular Biology
Poster > Graduate School of Biomedical Sciences > Biomedical Sciences, The Graduate School
Ajou Authors
대학, 생리학교실  |  대학, 생화학교실  |  대학원, 의생명과학과
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