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Reproducibility of hepatic MR elastography across field strengths, pulse sequences, scan intervals, and readers

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dc.contributor.authorKim, HJ-
dc.contributor.authorKim, B-
dc.contributor.authorYu, HJ-
dc.contributor.authorHuh, J-
dc.contributor.authorLee, JH-
dc.contributor.authorLee, SS-
dc.contributor.authorKim, KW-
dc.contributor.authorKim, JK-
dc.date.accessioned2022-10-24T05:53:29Z-
dc.date.available2022-10-24T05:53:29Z-
dc.date.issued2020-
dc.identifier.issn2366-004X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/22315-
dc.description.abstractPURPOSE: To evaluate the reproducibility of hepatic MRE under various combinations of settings of field strength, pulse sequence, scan interval, and reader in non-alcoholic fatty liver disease (NAFLD) patients.

METHODS: Adult NAFLD patients were prospectively enrolled for serial hepatic MRE with 1.5 T using 2D GRE sequence and 3.0 T using 2D SE-EPI sequence on the same day and after 2 weeks, resulting a total of four MRE examinations per patient. Three readers with various levels of background knowledge in MRE technique and liver anatomy measured liver stiffness after a training session. Linear regression, Bland-Altman analysis, within-subject coefficient of variation, and reproducibility coefficient (RDC) were used to determine reproducibility of hepatic MRE measurement.

RESULTS: Twenty patients completed the MRE sessions. Liver stiffness through MRE showed pooled RDC of 26% (upper 95% CI 30.6%) and corresponding limits of agreement (LOA) within 0.55 kPa across field strengths, MRE sequences, and 2-week interscan interval in three readers. Small mean biases and narrow LOA were observed among readers (0.05-0.19 kPa ± 0.53).

CONCLUSION: The magnitude of change across combinations of scan parameters is within acceptable clinical range, rendering liver stiffness through MRE a reproducible quantitative imaging biomarker. A lower reproducibility was observed for measurements under different field strengths/MRE sequences at a longer (2 weeks) interscan interval. Operators should be trained to acquire region of interest consistently in repeat examinations.
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dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHElasticity Imaging Techniques-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNon-alcoholic Fatty Liver Disease-
dc.subject.MESHProspective Studies-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHTime-
dc.subject.MESHYoung Adult-
dc.titleReproducibility of hepatic MR elastography across field strengths, pulse sequences, scan intervals, and readers-
dc.typeArticle-
dc.identifier.pmid31720766-
dc.subject.keywordMagnetic resonance elastography-
dc.subject.keywordNon-alcoholic fatty liver disease-
dc.subject.keywordReproducibility of results-
dc.contributor.affiliatedAuthorKim, B-
dc.contributor.affiliatedAuthorHuh, J-
dc.contributor.affiliatedAuthorLee, JH-
dc.contributor.affiliatedAuthorKim, JK-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00261-019-02312-9-
dc.citation.titleAbdominal radiology (New York)-
dc.citation.volume45-
dc.citation.number1-
dc.citation.date2020-
dc.citation.startPage107-
dc.citation.endPage115-
dc.identifier.bibliographicCitationAbdominal radiology (New York), 45(1). : 107-115, 2020-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn2366-0058-
dc.relation.journalidJ02366004X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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