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Epidemiology of community-acquired pneumonia in the era of extended serotype-covering multivalent pneumococcal conjugate vaccines

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dc.contributor.authorHeo, JY-
dc.contributor.authorSeo, YB-
dc.contributor.authorJeong, HW-
dc.contributor.authorChoi, MJ-
dc.contributor.authorMin, KH-
dc.contributor.authorChoi, WS-
dc.contributor.authorLee, J-
dc.contributor.authorNoh, JY-
dc.contributor.authorCheong, HJ-
dc.contributor.authorKim, WJ-
dc.contributor.authorSong, JY-
dc.date.accessioned2022-10-28T05:28:59Z-
dc.date.available2022-10-28T05:28:59Z-
dc.date.issued2020-
dc.identifier.issn0264-410X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/22490-
dc.description.abstractBACKGROUND: South Korea has been providing 10-valent pneumococcal conjugate vaccine/(PCV10)/13-valent pneumococcal conjugate vaccine (PCV13) to children and 23-valent pneumococcal polysaccharide vaccine (PPSV23) to older adults as part of a national immunization program.

METHODS: From September 2015 to August 2017, a prospective cohort study was conducted for adults aged >/=19 years with community-acquired pneumonia (CAP) at four university hospitals. All-cause and pneumococcal CAP incidence and mortality rates were evaluated on the basis of hospital catchment population. Serotype distribution of pneumococcal CAP was also evaluated.

RESULTS: Among 2669 patients with CAP, 252 cases (9.4%) were pneumococcal CAP cases. The annual incidences of all-cause and pneumococcal CAP were 194.3 cases and 18.3 cases respectively, per 100,000 persons. Serotyped Streptococcus pneumoniae was identified in 107 cases (42.5%) through culture or a serotype-specific urinary antigen detection assay. Pneumococcal CAP caused by the PCV13 and PPSV23 serotypes were 50 cases (46.7% of serotyped pneumococcal CAP and 19.8% of pneumococcal CAP), and 83 cases (77.6% of serotyped pneumococcal CAP and 32.9% of pneumococcal CAP), respectively. The most prevalent serotype was 3 (n = 21, 19.6% of serotyped pneumococcal CAP), followed by 19A (n = 10, 9.3% of serotyped pneumococcal CAP) and 11A (n = 10, 9.3% of serotyped pneumococcal CAP). Compared with non-pneumococcal CAP patients, pneumococcal CAP patients were more likely to have a higher CURB-65 scores (P = 0.002). The overall 30-day mortality rate of pneumococcal CAP was higher than that of non-pneumococcal CAP (6.3% versus 5.6%; odds ratio [OR], 1.15; 95% confidence interval [CI], 0.67-1.96), but this trend was reversed in patients aged 65-74 years (4.2% versus 8.6%; OR, 0.47; 95% CI, 0.14-1.54).

CONCLUSIONS: The disease burden of PCV13-serotype pneumococcal CAP remains significantly high in Korean adults, particularly among elderly people, even after a high uptake of pediatric PCVs.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHChild-
dc.subject.MESHHumans-
dc.subject.MESHPneumococcal Infections-
dc.subject.MESHPneumococcal Vaccines-
dc.subject.MESHPneumonia, Pneumococcal-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSerogroup-
dc.subject.MESHVaccines, Conjugate-
dc.subject.MESHYoung Adult-
dc.titleEpidemiology of community-acquired pneumonia in the era of extended serotype-covering multivalent pneumococcal conjugate vaccines-
dc.typeArticle-
dc.identifier.pmid33164798-
dc.subject.keywordCommunity-acquired pneumonia-
dc.subject.keywordEpidemiology-
dc.subject.keywordIncidence-
dc.subject.keywordMortality-
dc.subject.keywordPneumococcus-
dc.contributor.affiliatedAuthorHeo, JY-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.vaccine.2020.10.046-
dc.citation.titleVaccine-
dc.citation.volume38-
dc.citation.number49-
dc.citation.date2020-
dc.citation.startPage7747-
dc.citation.endPage7755-
dc.identifier.bibliographicCitationVaccine, 38(49). : 7747-7755, 2020-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1873-2518-
dc.relation.journalidJ00264410X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Infectious Diseases
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