Cited 0 times in Scipus Cited Count

Crosstalk between head and neck cancer cells and lymphatic endothelial cells promotes tumor metastasis via CXCL5-CXCR2 signaling

DC Field Value Language
dc.contributor.authorLee, BS-
dc.contributor.authorJang, JY-
dc.contributor.authorSeo, C-
dc.contributor.authorKim, CH-
dc.date.accessioned2022-11-11T04:09:30Z-
dc.date.available2022-11-11T04:09:30Z-
dc.date.issued2021-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/22531-
dc.description.abstractHead and neck squamous cell carcinoma (HNSCC) metastasizes to the locoregional lymph nodes at high rates and is related to poor clinical outcomes. However, the mechanism by which cancer cells migrate to the lymph nodes is unclear. To address this, we established a conditioned medium culture system for HNSCC cells and lymphatic endothelial cells (LECs) and investigated their crosstalk. Stimulation with tumor-conditioned medium (TCM) activated LECs, resulting in a robust increase in cell proliferation to induce lymphatic hyperplasia. Further, stimulation of HNSCC cells with activated LEC Conditioned media (TCM-LEC CM) induced cell invasion. Among various chemokines, CXCL5 promoted the invasion of TCM-LEC CM-treated HNSCC cells. The level of CXCL5 protein was higher in cancer tissues than those in normal tissues from HNSCC patients. Furthermore, treatment with SB225002, a CXCR2 (CXCL5 receptor) inhibitor, resulted in decreased lymph node metastasis in vivo. In conclusion, inhibition of CXCL5-CXCR2 signaling between cancer cells and LECs suppresses cancer cell invasion and metastasis in vitro and in vivo. This novel therapeutic strategy might be a practical approach to the clinical management of HNSCC.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHCell Communication-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHChemokine CXCL5-
dc.subject.MESHEndothelial Cells-
dc.subject.MESHFemale-
dc.subject.MESHHead and Neck Neoplasms-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHNeoplasm Proteins-
dc.subject.MESHReceptors, Interleukin-8B-
dc.subject.MESHSignal Transduction-
dc.titleCrosstalk between head and neck cancer cells and lymphatic endothelial cells promotes tumor metastasis via CXCL5-CXCR2 signaling-
dc.typeArticle-
dc.identifier.pmid33231340-
dc.subject.keywordCXCL5-
dc.subject.keywordHNSCC-
dc.subject.keywordinvasion-
dc.subject.keywordlymph node-
dc.subject.keywordmigration-
dc.contributor.affiliatedAuthorLee, BS-
dc.contributor.affiliatedAuthorJang, JY-
dc.contributor.affiliatedAuthorKim, CH-
dc.type.localJournal Papers-
dc.identifier.doi10.1096/fj.202001455R-
dc.citation.titleFASEB journal-
dc.citation.volume35-
dc.citation.number1-
dc.citation.date2021-
dc.citation.startPagee21181-
dc.citation.endPagee21181-
dc.identifier.bibliographicCitationFASEB journal, 35(1). : e21181-e21181, 2021-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1530-6860-
dc.relation.journalidJ008926638-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse