Cited 0 times in Scipus Cited Count

Clinical and Laboratory Findings of Barley Allergy in Korean Children: a Single Hospital Based Retrospective Study

DC Field Value Language
dc.contributor.authorLee, E-
dc.contributor.authorJeong, K-
dc.contributor.authorLee, J-
dc.contributor.authorJeon, SA-
dc.contributor.authorPark, B-
dc.contributor.authorLee, H-
dc.contributor.authorLee, S-
dc.date.accessioned2022-11-11T04:09:36Z-
dc.date.available2022-11-11T04:09:36Z-
dc.date.issued2020-
dc.identifier.issn1011-8934-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/22556-
dc.description.abstractBACKGROUND: Barley is a grain that is consumed in various forms in Asia. Studies on barley allergy are limited to a few case reports about hypersensitivity reactions to beer, but there is no barley allergy study in children. This study aimed to identify the phenotype and immunologic findings in Korean children with barley allergy. METHODS: Forty-two participants with a history of ingesting barley who underwent serum specific immunoglobulin E to barley (barley-sIgE) assay at the Department of Pediatrics in Ajou Medical Center were enrolled through a retrospective analysis of medical records from March 2008 to February 2018. The demographic characteristics, symptoms, and immunologic parameters of the patients were assessed. RESULTS: Twenty subjects presented with clinical barley allergy (B-allergic group), and 22 were atopic controls without allergic reactions after the ingestion of barley (B-tolerant group). The median ages of the B-allergic and B-tolerant groups were 1 and 3 years, respectively. In the B-allergic group, the cutaneous system (90.0%) was most frequently affected, followed by the respiratory system (40.0%). Anaphylaxis was observed in 35.0% of the B-allergic group. The median level of barley-sIgE was 13.90 kUA/L (range, 0.14-101.00 kUA/L) in the B-allergic group, and this value was significantly higher (P < 0.001) than that of the B-tolerant group (0.30 kUA/L; range, 0.01-24.40 kUA/L), with an optimal cutoff level of 1.24 kUA/L (sensitivity, 85.0%; specificity, 86.4%). A positive correlation was found between the serum levels of barley-sIgE and wheat-sIgE in the B-allergic group with clinical wheat allergy. CONCLUSION: Barley is an important allergen for children in Korea. This study showed the clinical characteristics of barley allergy and suggested optimal cut-off levels of barley-sIgE for clinical barley allergy. Clinically, cross-reactivity or co-sensitization is often observed between barley and wheat.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAllergens-
dc.subject.MESHAnaphylaxis-
dc.subject.MESHArea Under Curve-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDermatitis, Atopic-
dc.subject.MESHFemale-
dc.subject.MESHFood Hypersensitivity-
dc.subject.MESHHordeum-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E-
dc.subject.MESHInfant-
dc.subject.MESHMale-
dc.subject.MESHROC Curve-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.titleClinical and Laboratory Findings of Barley Allergy in Korean Children: a Single Hospital Based Retrospective Study-
dc.typeArticle-
dc.identifier.pmid31950778-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970078-
dc.subject.keywordAnaphylaxis-
dc.subject.keywordBarley Allergy-
dc.subject.keywordFood Allergy-
dc.subject.keywordSpecific IgE-
dc.contributor.affiliatedAuthorJeong, K-
dc.contributor.affiliatedAuthorPark, B-
dc.contributor.affiliatedAuthorLee, S-
dc.type.localJournal Papers-
dc.identifier.doi10.3346/jkms.2020.35.e23-
dc.citation.titleJournal of Korean medical science-
dc.citation.volume35-
dc.citation.number3-
dc.citation.date2020-
dc.citation.startPagee23-
dc.citation.endPagee23-
dc.identifier.bibliographicCitationJournal of Korean medical science, 35(3). : e23-e23, 2020-
dc.identifier.eissn1598-6357-
dc.relation.journalidJ010118934-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
Files in This Item:
31950778.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse