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Airflow limitation as a risk factor for vascular stiffness

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dc.contributor.authorSheen, SS-
dc.contributor.authorKim, HJ-
dc.contributor.authorSingh, D-
dc.contributor.authorHwang, SC-
dc.contributor.authorPark, KJ-
dc.contributor.authorAhn, SV-
dc.contributor.authorLee, E-
dc.contributor.authorPark, B-
dc.contributor.authorJung, JH-
dc.contributor.authorPark, RW-
dc.contributor.authorKim, JH-
dc.contributor.authorPark, HS-
dc.contributor.authorPark, JH-
dc.date.accessioned2022-11-11T04:09:41Z-
dc.date.available2022-11-11T04:09:41Z-
dc.date.issued2020-
dc.identifier.issn1027-3719-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/22583-
dc.description.abstractBACKGROUND: Cardiovascular disease is one of the main causes of mortality in patients with chronic obstructive pulmonary disease (COPD), and atherosclerosis is a cause of cardiac comorbidities in COPD. However, it is not clear whether airflow limitation is associated with atherosclerosis irrespective of smoking.

OBJECTIVE: To investigate whether airflow limitation is independently associated with vascular stiffness.

METHODS: We enrolled 18 893 participants (male 70.5%; mean age 47.5 +/- 9.8 years; never smokers 44.2%) who underwent spirometry and brachial-ankle pulse wave velocity (baPWV) as part of a standard health examination at Ajou University Hospital, Suwon, South Korea, from January 2010 to December 2015.We defined vascular peripheral atherosclerosis as baPWV >/= 1400 cm/s and airflow limitation as pre-bronchodilator ratio of forced expiratory volume in 1 sec (FEV1) to forced vital capacity (FVC) <70%.

RESULTS: Mean baPWV was higher in subjects with airflow limitation (1477.6 +/- 331.7 cm/sec, n = 638) than in those without airflow limitation (1344.1 +/- 231.8 cm/sec, n = 18255, P < 0.001). In multivariate logistic regression analysis, the following were independent predictors associated with peripheral atherosclerosis (P < 0.05): age, male sex, fasting serum glucose, mean blood pressure, serum leukocyte count, serum low density lipoprotein level and FEV1.

CONCLUSION: Airflow limitation was an independent predictor of vascular stiffness irrespective of smoking history, which suggests that airflow limitation is linked with atherosclerosis.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAnkle Brachial Index-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPulmonary Disease, Chronic Obstructive-
dc.subject.MESHPulse Wave Analysis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHSpirometry-
dc.subject.MESHVascular Stiffness-
dc.subject.MESHVital Capacity-
dc.titleAirflow limitation as a risk factor for vascular stiffness-
dc.typeArticle-
dc.identifier.pmid32552994-
dc.subject.keywordairflow limitation-
dc.subject.keywordatherosclerosis-
dc.subject.keywordsmoking-
dc.contributor.affiliatedAuthorSheen, SS-
dc.contributor.affiliatedAuthorHwang, SC-
dc.contributor.affiliatedAuthorPark, KJ-
dc.contributor.affiliatedAuthorPark, B-
dc.contributor.affiliatedAuthorPark, RW-
dc.contributor.affiliatedAuthorKim, JH-
dc.contributor.affiliatedAuthorPark, HS-
dc.contributor.affiliatedAuthorPark, JH-
dc.type.localJournal Papers-
dc.identifier.doi10.5588/ijtld.19.0457-
dc.citation.titleThe international journal of tuberculosis and lung disease-
dc.citation.volume24-
dc.citation.number6-
dc.citation.date2020-
dc.citation.startPage577-
dc.citation.endPage584-
dc.identifier.bibliographicCitationThe international journal of tuberculosis and lung disease, 24(6). : 577-584, 2020-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1815-7920-
dc.relation.journalidJ010273719-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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