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Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas.

DC Field Value Language
dc.contributor.authorKim, SH-
dc.contributor.authorKim, JW-
dc.contributor.authorKim, YT-
dc.contributor.authorKim, JH-
dc.contributor.authorYoon, BS-
dc.contributor.authorRyu, HS-
dc.date.accessioned2011-04-13T05:34:52Z-
dc.date.available2011-04-13T05:34:52Z-
dc.date.issued2006-
dc.identifier.issn0020-7292-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2269-
dc.description.abstractOBJECTIVES: To evaluate the clinicopathologic prognostic factors of uterine sarcoma, and determine whether overexpression of p53 and mdm-2 proteins correlate with overall survival and prognostic factors.



METHODS: Thirty specimens from 43 patients with uterine sarcoma were available for slide review and evaluated by immunohistochemistry at Yonsei and Ajou University Medical Centers for the expression of p53 and mdm-2.



RESULTS: Overall survival was found to correlate to histologic type of uterine sarcoma, surgical stage, tumor grade, and mitotic index. Whereas 63% of the sarcomas expressed p53, with a significant correlation to overall survival, 60% expressed mdm-2, with a significant correlation to the mitotic index but not to overall survival.



CONCLUSION: Histologic type, surgical stage, tumor grade, mitotic index, and p53 expression were prognostic factors of the overall survival of patients with uterine sarcoma.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression/physiology-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKorea-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging/adverse effects*-
dc.subject.MESHPrognosis-
dc.subject.MESHProto-Oncogene Proteins c-mdm2/metabolism*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSarcoma/metabolism*-
dc.subject.MESHSarcoma/pathology-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTumor Suppressor Protein p53/metabolism*-
dc.subject.MESHUp-Regulation/physiology-
dc.subject.MESHUterine Neoplasms/metabolism*-
dc.subject.MESHUterine Neoplasms/pathology-
dc.titlePrognostic factors and expression of p53 and mdm-2 in uterine sarcomas.-
dc.typeArticle-
dc.identifier.pmid16930603-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0020-7292(06)00164-0-
dc.contributor.affiliatedAuthor유, 희석-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ijgo.2006.03.031-
dc.citation.titleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics-
dc.citation.volume95-
dc.citation.number3-
dc.citation.date2006-
dc.citation.startPage272-
dc.citation.endPage277-
dc.identifier.bibliographicCitationInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 95(3):272-277, 2006-
dc.identifier.eissn1879-3479-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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