Daylight photodynamic therapy with ablative carbon dioxide fractional laser for treating actinic keratosis in Asians: A case series

Abstract

Photodynamic Therapy (PDT) is one of the standard treatment modalities for actinic keratoses (AKs). Daylight PDT (DL-PDT) with MAL cream, using daylight as light source, is one of recent treatment for AKs with less pain. Herein, we report cases of AKs successfully treated with DL-PDT in Asian patients. Four patients presented erythematous scaly patches and were diagnosed with AK by skin biopsy. The lesions were pretreated by fractional carbon dioxide laser first and then MAL creams were applied immediately. They went outdoors and exposed daylight for 2 h. They reported little pain of visual analogue scale 0. Clinically cleared lesions were observed with 1 month and 2 month follow-up. No complication such as oozing or scar was reported.