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Calcium uptake and release through sarcoplasmic reticulum in the inferior oblique muscles of patients with inferior oblique overaction.

Authors
Kim, HS; Chang, YH; Kim, DH; Park, SR; Han, SH; Lee, JB
Citation
Yonsei medical journal, 47(2):207-213, 2006
Journal Title
Yonsei medical journal
ISSN
0513-57961976-2437
Abstract
We characterized and compared the characteristics of Ca2+ movements through the sarcoplasmic reticulum of inferior oblique muscles in the various conditions including primary inferior oblique overaction (IOOA), secondary IOOA, and controls, so as to further understand the pathogenesis of primary IOOA. Of 15 specimens obtained through inferior oblique myectomy, six were from primary IOOA, 6 from secondary IOOA, and the remaining 3 were controls from enucleated eyes. Ryanodine binding assays were performed, and Ca2+ uptake rates, calsequestrins and SERCA levels were determined. Ryanodine bindings and sarcoplasmic reticulum Ca2+ uptake rates were significantly decreased in primary IOOA (p < 0.05). Western blot analysis conducted to quantify calsequestrins and SERCA, found no significant difference between primary IOOA, secondary IOOA, and the controls. Increased intracellular Ca2+ concentration due to reduced sarcoplasmic reticulum Ca2+ uptake may play a role in primary IOOA.
MeSH terms
AdolescentAdultAgedBlotting, WesternCalcium/metabolismCalcium/pharmacokinetics*Calcium-Transporting ATPases/metabolismCalsequestrin/metabolismChildChild, PreschoolFemaleHumansMaleMiddle AgedModels, StatisticalMuscles/pathology*Ocular Motility Disorders/metabolism*Ocular Motility Disorders/pathology*Oculomotor MusclesOxalates/metabolismRyanodine/metabolismRyanodine Receptor Calcium Release Channel/metabolismSarcoplasmic Reticulum/metabolism*Sarcoplasmic Reticulum Calcium-Transporting ATPases
DOI
10.3349/ymj.2006.47.2.207
PMID
16642550
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Ophthalmology
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