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Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma.

Kim, CH; Moon, SK; Bae, JH; Lee, JH; Han, JH; Kim, K; Choi, EC
Acta oto-laryngologica, 126(1):88-94, 2006
Journal Title
Acta oto-laryngologica
CONCLUSION: Our results suggest that hepatocyte growth factor (HGF) may play an important role in the progression of hypopharyngeal cancer.

OBJECTIVE: HGF, a potent stimulator of hepatocyte growth, stimulates the motility, invasiveness, proliferation and morphogenesis of epithelium and may be involved in physiologic and pathologic processes such as embryogenesis, wound healing, organ regeneration, inflammation and tumor invasion. We therefore examined the role of HGF and c-Met in the invasion and metastasis of hypopharyngeal squamous cell carcinoma (SCC).

MATERIAL AND METHODS: We performed immunohistochemical staining of 40 specimens each of normal mucosa and SCC of the hypopharynx with HGF and c-Met antibodies. For reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting, fresh normal and cancer tissue from the hypopharynx obtained from five patients were used.

RESULTS: Positive rates of HGF and c-Met expression in hypopharyngeal SCC were 77.5% and 70%, respectively. HGF staining was significantly correlated with lymph node metastasis and pathologic stage (p < 0.05). c-Met staining was only significantly correlated with lymph node metastasis (p < 0.05). Increased expression of c-Met mRNA (RT-PCR) and protein (Western blotting) was detected in hypopharyngeal cancer tissue.
MeSH terms
AdultAgedBlotting, WesternCarcinoma, Squamous Cell/metabolismCarcinoma, Squamous Cell/pathology*Gene Expression Regulation, NeoplasticHepatocyte Growth Factor/geneticsHepatocyte Growth Factor/metabolism*HumansHypopharyngeal Neoplasms/metabolismHypopharyngeal Neoplasms/pathology*ImmunohistochemistryMiddle AgedNeoplasm StagingProto-Oncogene Proteins c-met/geneticsProto-Oncogene Proteins c-met/metabolism*RNA/analysisReverse Transcriptase Polymerase Chain Reaction
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
김, 철호이, 재호한, 재호
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