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Intratympanic dexamethasone injection for refractory sudden sensorineural hearing loss.

Authors
Choung, YH; Park, K; Shin, YR; Cho, MJ
Citation
The Laryngoscope, 116(5):747-752, 2006
Journal Title
The Laryngoscope
ISSN
0023-852X1531-4995
Abstract
OBJECTIVE: This case-control study aimed to analyze the effect of intratympanic dexamethasone injection (ITDI) as a treatment option for patients with sudden sensorineural hearing loss (SSNHL) who were refractory to classic oral steroid treatment. METHODS: Sixty-six patients with SSNHL, who were refractory to a course of oral steroid therapy, were included in this study. We prospectively treated consecutive 33 patients (34 ears) with ITDI from August 2002 to January 2004. We then retrospectively collected data from age- and sex-matched previous patients who did not take any more treatments after the initial regimen between March 2000 and July 2002. ITDI was performed in the supine position on four separate occasions over the course of 2 weeks. Hearing was assessed immediately before every injection and at 1 week after therapy. Hearing improvement was defined as more than 10 dB in pure-tone average (PTA). RESULTS: Hearing improvement was observed in 13 (39.4%) of 33 patients who underwent ITDI and in two (6.1%) of 33 patients in the control group. Five of 13 represented hearing improvement over than 20 dB in PTA, and 11 of 20 patients, who showed no improvement in PTA by ITDI, showed improvement over 10 dB in some frequencies. There were no definite prognostic factors between the patients who responded to ITDI and those who did not. CONCLUSION: ITDI may be a simple and effective therapy for patients with refractory SSNHL.
MeSH terms
Administration, OralAdrenal Cortex Hormones/therapeutic useAdultAnti-Inflammatory Agents/administration & dosage*Audiometry, Pure-Tone/methodsCase-Control StudiesDexamethasone/administration & dosage*Dose-Response Relationship, DrugDrug Administration ScheduleDrug ResistanceFemaleFollow-Up StudiesHearing Loss, Sensorineural/diagnosisHearing Loss, Sensorineural/drug therapy*Hearing Loss, Sudden/diagnosisHearing Loss, Sudden/surgery*HumansInjections, IntralesionalMaleProbabilityRetrospective StudiesRisk AssessmentSeverity of Illness IndexTreatment OutcomeTympanic Membrane/drug effects*
DOI
10.1097/01.mlg.0000205183.29986.f6
PMID
16652082
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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